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- W2034348439 abstract "The pharmacological antagonistic properties of the invertebrate specific octopamine receptor were investigated using a conventional radio-receptor assay with [3H]octopamine as the radioligand. Among the antagonists with highest affinity of the locust (Locusta migratoria L.) neuronal octopamine receptor were tetracyclic substances like mianserin (k1 = 1.2 nM), some of its derivatives (8-hydroxymianserin;K1 = 1.68 nM), and maroxepine, which is the antagonist with the highest affinity ever reported (K1 = 1.02 nM) to this octopamine receptor class. Among the other antagonists tested only phentolamine (K1 = 19 nM) and promethazine (K1 = 31.2 nM) had high-affinity properties." @default.
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- W2034348439 date "1990-11-01" @default.
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- W2034348439 title "High-affinity antagonists of the locust neuronal octopamine receptor" @default.
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- W2034348439 doi "https://doi.org/10.1016/0014-2999(90)94151-m" @default.
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