Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034349076> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2034349076 endingPage "2627" @default.
- W2034349076 startingPage "2617" @default.
- W2034349076 abstract "A balance of the activities of multiple enzymes maintains the typical asymmetry of plasma membrane lipids in healthy cells. Such enzyme activities are (a) the aminophopholipid translocase (APTL) (a lipid-selective P-type ATPase that catalyzes inward movement of aminophospholipids), (b) the scramblase (a calcium-dependent and ATP-independent enzyme that catalyzes both inward and outward movement of lipids), (c) the floppase (an ATP-dependent enzyme that catalyzes only outward movement of lipids). Activation or inhibition of any one of these enzymes would lead to a loss in this asymmetry. Apoptosis-associated externalization of phophatidylserine has been reported for many different cell-types, but the exact mechanism involved in this loss of membrane asymmetry has not been identified yet. In this report we demonstrate concurrence of APTL inhibition, caspase-3 activation and apoptosis in CNS-derived HN2-5 and HOG cells. Additionally, we provide data to demonstrate that the phagocytosis of apoptotic, CNS-derived HN2-5 cells by the microglial cells requires recognition through phosphatidylserine (PS). Thus the enzyme aminopholipid translocase is inhibited during apoptosis of CNS-derived cells and this alone could account for the loss of plasma membrane lipid-asymmetry observed in these cells." @default.
- W2034349076 created "2016-06-24" @default.
- W2034349076 creator A5019961826 @default.
- W2034349076 creator A5025871789 @default.
- W2034349076 creator A5050697108 @default.
- W2034349076 date "2003-04-01" @default.
- W2034349076 modified "2023-09-27" @default.
- W2034349076 title "Apoptosis is associated with an inhibition of aminophospholipid translocase (APTL) in CNS-derived HN2-5 and HOG cells and phosphatidylserine is a recognition molecule in microglial uptake of the apoptotic HN2-5 cells" @default.
- W2034349076 cites W107210068 @default.
- W2034349076 cites W1483697181 @default.
- W2034349076 cites W1557686543 @default.
- W2034349076 cites W1646206347 @default.
- W2034349076 cites W165853039 @default.
- W2034349076 cites W1984376924 @default.
- W2034349076 cites W1990345081 @default.
- W2034349076 cites W1992940854 @default.
- W2034349076 cites W1994218433 @default.
- W2034349076 cites W1996180957 @default.
- W2034349076 cites W2016319161 @default.
- W2034349076 cites W2048397445 @default.
- W2034349076 cites W2089267729 @default.
- W2034349076 cites W2116060644 @default.
- W2034349076 cites W2131785128 @default.
- W2034349076 cites W2328105170 @default.
- W2034349076 doi "https://doi.org/10.1016/s0024-3205(03)00163-2" @default.
- W2034349076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12672507" @default.
- W2034349076 hasPublicationYear "2003" @default.
- W2034349076 type Work @default.
- W2034349076 sameAs 2034349076 @default.
- W2034349076 citedByCount "21" @default.
- W2034349076 countsByYear W20343490762021 @default.
- W2034349076 countsByYear W20343490762022 @default.
- W2034349076 crossrefType "journal-article" @default.
- W2034349076 hasAuthorship W2034349076A5019961826 @default.
- W2034349076 hasAuthorship W2034349076A5025871789 @default.
- W2034349076 hasAuthorship W2034349076A5050697108 @default.
- W2034349076 hasConcept C104317684 @default.
- W2034349076 hasConcept C113035283 @default.
- W2034349076 hasConcept C138626823 @default.
- W2034349076 hasConcept C181199279 @default.
- W2034349076 hasConcept C185592680 @default.
- W2034349076 hasConcept C188810444 @default.
- W2034349076 hasConcept C190283241 @default.
- W2034349076 hasConcept C2778918659 @default.
- W2034349076 hasConcept C2779637612 @default.
- W2034349076 hasConcept C41625074 @default.
- W2034349076 hasConcept C55493867 @default.
- W2034349076 hasConcept C86803240 @default.
- W2034349076 hasConcept C95444343 @default.
- W2034349076 hasConceptScore W2034349076C104317684 @default.
- W2034349076 hasConceptScore W2034349076C113035283 @default.
- W2034349076 hasConceptScore W2034349076C138626823 @default.
- W2034349076 hasConceptScore W2034349076C181199279 @default.
- W2034349076 hasConceptScore W2034349076C185592680 @default.
- W2034349076 hasConceptScore W2034349076C188810444 @default.
- W2034349076 hasConceptScore W2034349076C190283241 @default.
- W2034349076 hasConceptScore W2034349076C2778918659 @default.
- W2034349076 hasConceptScore W2034349076C2779637612 @default.
- W2034349076 hasConceptScore W2034349076C41625074 @default.
- W2034349076 hasConceptScore W2034349076C55493867 @default.
- W2034349076 hasConceptScore W2034349076C86803240 @default.
- W2034349076 hasConceptScore W2034349076C95444343 @default.
- W2034349076 hasIssue "23" @default.
- W2034349076 hasLocation W20343490761 @default.
- W2034349076 hasLocation W20343490762 @default.
- W2034349076 hasOpenAccess W2034349076 @default.
- W2034349076 hasPrimaryLocation W20343490761 @default.
- W2034349076 hasRelatedWork W1871390418 @default.
- W2034349076 hasRelatedWork W1991880183 @default.
- W2034349076 hasRelatedWork W1997673080 @default.
- W2034349076 hasRelatedWork W2002416967 @default.
- W2034349076 hasRelatedWork W2025406853 @default.
- W2034349076 hasRelatedWork W2047473325 @default.
- W2034349076 hasRelatedWork W2066171290 @default.
- W2034349076 hasRelatedWork W2066198761 @default.
- W2034349076 hasRelatedWork W2079399167 @default.
- W2034349076 hasRelatedWork W2912279372 @default.
- W2034349076 hasVolume "72" @default.
- W2034349076 isParatext "false" @default.
- W2034349076 isRetracted "false" @default.
- W2034349076 magId "2034349076" @default.
- W2034349076 workType "article" @default.