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• W203434945 startingPage "F283" @default.
• W203434945 abstract "Heavy metal intoxication leads to a number of reabsorptive and secretory defects in renal transport systems. We have studied the effects of several heavy metals on the expression of the renal Na-Si cotransporter NaSi-1. NaSi-1 cRNA was injected into Xenopus oocytes, and Na-Si cotransport activity was measured in the presence of mercury, lead, cadmium, or chromium. Mercury strongly inhibited NaSi-1 transport irreversibly by reducing both maximal velocity (Vmax) and Michaelis constant (Km) for inorganic sulfate (Si). Lead inhibited NaSi-1 transport reversibly by decreasing Vmax but not Km for Si. Cadmium showed weak reversible inhibition of NaSi-1 transport by decreasing only NaSi-1 Vmax. Chromium strongly inhibited NaSi-1 cotransport reversibly by reducing Km for Si by sevenfold, most probably by binding to the Si site, due to the strong structural similarity between the CrO4(2-) and SO4(2-) substrates. In conclusion, this study presents an initial report demonstrating heavy metals inhibit renal brush border Na-Si cotransport via the NaSi-1 protein through various mechanisms and that this blockade may be responsible for sulfaturia following heavy metal intoxication." @default.
• W203434945 created "2016-06-24" @default.
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• W203434945 creator A5059424079 @default.
• W203434945 date "1998-02-01" @default.
• W203434945 modified "2023-09-26" @default.
• W203434945 title "Renal Na-S_icotransporter NaSi-1 is inhibited by heavy metals" @default.
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• W203434945 doi "https://doi.org/10.1152/ajprenal.1998.274.2.f283" @default.
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