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• W2034349585 endingPage "1150" @default.
• W2034349585 startingPage "1135" @default.
• W2034349585 abstract "Hepatitis C virus (HCV) is a blood-borne pathogen that was identified as an etiologic agent of non-A, non-B hepatitis in 1989. HCV is estimated to have infected at least 170 million people worldwide. The majority of patients infected with HCV do not clear the virus and become chronically infected, and chronic HCV infection increases the risk for hepatic steatosis, cirrhosis, and hepatocellular carcinoma. HCV induces oxidative/nitrosative stress from multiple sources, including inducible nitric oxide synthase, the mitochondrial electron transport chain, hepatocyte NAD(P)H oxidases, and inflammation, while decreasing glutathione. The cumulative oxidative burden is likely to promote both hepatic and extrahepatic conditions precipitated by HCV through a combination of local and more distal effects of reactive species, and clinical, animal, and in vitro studies strongly point to a role of oxidative/nitrosative stress in HCV-induced pathogenesis. Oxidative stress and hepatopathogenesis induced by HCV are exacerbated by even low doses of alcohol. Alcohol and reactive species may have other effects on hepatitis C patients such as modulation of the host immune system, viral replication, and positive selection of HCV sequence variants that contribute to antiviral resistance. This review summarizes the current understanding of redox interactions of HCV, outlining key experimental findings, directions for future research, and potential applications to therapy." @default.
• W2034349585 created "2016-06-24" @default.
• W2034349585 creator A5022255793 @default.
• W2034349585 date "2012-04-01" @default.
• W2034349585 modified "2023-10-02" @default.
• W2034349585 title "Oxidative stress, endogenous antioxidants, alcohol, and hepatitis C: pathogenic interactions and therapeutic considerations" @default.
• W2034349585 cites W1498307929 @default.
• W2034349585 cites W1541967458 @default.
• W2034349585 cites W1542737599 @default.
• W2034349585 cites W1547863599 @default.
• W2034349585 cites W1585390661 @default.
• W2034349585 cites W1589430668 @default.
• W2034349585 cites W1623473717 @default.
• W2034349585 cites W1821918060 @default.
• W2034349585 cites W1825284425 @default.
• W2034349585 cites W1827885532 @default.
• W2034349585 cites W1838530486 @default.
• W2034349585 cites W1855396097 @default.
• W2034349585 cites W1920234850 @default.
• W2034349585 cites W1959404743 @default.
• W2034349585 cites W1964190328 @default.
• W2034349585 cites W1965957362 @default.
• W2034349585 cites W1966672647 @default.
• W2034349585 cites W1967151851 @default.
• W2034349585 cites W1967173409 @default.
• W2034349585 cites W1967716194 @default.
• W2034349585 cites W1968832843 @default.
• W2034349585 cites W1969728880 @default.
• W2034349585 cites W1970469656 @default.
• W2034349585 cites W1971215115 @default.
• W2034349585 cites W1971464824 @default.
• W2034349585 cites W1971818550 @default.
• W2034349585 cites W1972228563 @default.
• W2034349585 cites W1972559150 @default.
• W2034349585 cites W1973346087 @default.
• W2034349585 cites W1976172595 @default.
• W2034349585 cites W1976390590 @default.
• W2034349585 cites W1976887467 @default.
• W2034349585 cites W1977303761 @default.
• W2034349585 cites W1977489187 @default.
• W2034349585 cites W1978883570 @default.
• W2034349585 cites W1982088059 @default.
• W2034349585 cites W1982327750 @default.
• W2034349585 cites W1982628122 @default.
• W2034349585 cites W1982990246 @default.
• W2034349585 cites W1983104963 @default.
• W2034349585 cites W1983770444 @default.
• W2034349585 cites W1984150038 @default.
• W2034349585 cites W1984797661 @default.
• W2034349585 cites W1985015226 @default.
• W2034349585 cites W1985432367 @default.
• W2034349585 cites W1986551392 @default.
• W2034349585 cites W1986852176 @default.
• W2034349585 cites W1987002413 @default.
• W2034349585 cites W1987763288 @default.
• W2034349585 cites W1987830420 @default.
• W2034349585 cites W1987984630 @default.
• W2034349585 cites W1988045726 @default.
• W2034349585 cites W1988594495 @default.
• W2034349585 cites W1989368291 @default.
• W2034349585 cites W1989831705 @default.
• W2034349585 cites W1989916371 @default.
• W2034349585 cites W1990057587 @default.
• W2034349585 cites W1992190909 @default.
• W2034349585 cites W1993573765 @default.
• W2034349585 cites W1994164027 @default.
• W2034349585 cites W1994742809 @default.
• W2034349585 cites W1995811312 @default.
• W2034349585 cites W1997268973 @default.
• W2034349585 cites W1997948093 @default.
• W2034349585 cites W1998073026 @default.
• W2034349585 cites W1998171008 @default.
• W2034349585 cites W1999928435 @default.
• W2034349585 cites W2000430197 @default.
• W2034349585 cites W2001771411 @default.
• W2034349585 cites W2002120703 @default.
• W2034349585 cites W2002123263 @default.
• W2034349585 cites W2003579943 @default.
• W2034349585 cites W2003869981 @default.
• W2034349585 cites W2004360699 @default.
• W2034349585 cites W2009066214 @default.
• W2034349585 cites W2009228935 @default.
• W2034349585 cites W2009301192 @default.
• W2034349585 cites W2011116922 @default.
• W2034349585 cites W2011500811 @default.
• W2034349585 cites W2011616562 @default.
• W2034349585 cites W2013163515 @default.
• W2034349585 cites W2013816787 @default.
• W2034349585 cites W2015098253 @default.
• W2034349585 cites W2015748566 @default.
• W2034349585 cites W2015783029 @default.
• W2034349585 cites W2016106891 @default.
• W2034349585 cites W2017421642 @default.
• W2034349585 cites W2018643603 @default.
• W2034349585 cites W2018871095 @default.
• W2034349585 cites W2020471249 @default.
• W2034349585 cites W2021199098 @default.
• W2034349585 cites W2022976224 @default.

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