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• W2034351630 endingPage "106" @default.
• W2034351630 startingPage "102" @default.
• W2034351630 abstract "In MG, anti-AChR or anti-MuSK abs impair neuromuscular transmission. Partial inhibition of AChE can ameliorate symptoms, while a complete block causes a cholinergic blockade. We found anti-AChE abs in 115/240 MG patients, with no correlation with sex, age at onset, thymus pathology, presence of anti-AChR or anti-MuSK antibodies. We found a correlation with the ocular form of the disease, and with milder forms of MG not requiring immunosuppressants; moreover, when we considered only those patients who were off AChEI therapy, we found that ocular patients were positive for anti-AChE abs, while generalized patients were negative. According to an experimental model, we hypothesize that anti-AChE abs could contribute to ptosis through an inhibition of the sympathetic innervation of the tarsal muscle." @default.
• W2034351630 created "2016-06-24" @default.
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• W2034351630 date "2010-01-01" @default.
• W2034351630 modified "2023-10-10" @default.
• W2034351630 title "Anti-acetylcholinesterase antibodies associate with ocular myasthenia gravis" @default.
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• W2034351630 doi "https://doi.org/10.1016/j.jneuroim.2009.11.004" @default.
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