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- W2034352415 abstract "Hypoglycemia of sufficient severity to cause cessation of EEG activity (coma) is accompanied by energy failure and by loss of ion homeostasis, the latter encompassing a marked rise in extracellular fluid (ECF) K + concentration and a fall in ECF Ca 2+ concentration. Presumably, ECF Na + concentration decreases as well. In the present study, the extent that the altered ECF-plasma gradients give rise to net ion fluxes between plasma and tissue is explored. Accordingly, whole tissue contents of Ca 2+ , Mg 2+ , K + , and Na + were measured. The experiments were carried out in anaesthetized and artificially ventilated rats given insulin i.p.; cerebral cortical tissue was sampled at the stage of slow-wave EEG activity, after 10, 30, and 60 min of coma (defined as isoelectric EEG), as well as after 1.5, 6, and 24 h of recovery. In the precomatose animals (with a slow-wave EEG pattern), no changes in electrolyte contents were observed. During coma, tissue Na + content increased progressively and the K + content fell (each by 20 μmol g −1 during 60 min). During recovery, these alterations were reversed within the first 6 h. The Mg 2+ content remained unchanged. In spite of the appreciable plasma to ECF Ca 2+ gradient, no significant calcium accumulation was observed. It is concluded that hypoglycemia leads to irreversible neuronal necrosis in the absence of gross accumulation of calcium in the tissue." @default.
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- W2034352415 date "1987-12-01" @default.
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- W2034352415 title "Electrolyte Shifts between Brain and Plasma in Hypoglycemic Coma" @default.
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- W2034352415 doi "https://doi.org/10.1038/jcbfm.1987.135" @default.
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