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• W2034352587 abstract "Background/Aims: The effect of daily injections with genistein (naturally occurring phytoestrogen) on intestinal chloride (Cl-) secretion was measured with Ussing chamber short circuit current (Isc, µA/cm2), in C57BL/6J male and female mice, using 600 mg/kg genistein/day (600G), 300 mg/kg genistein/day (300G), 150 mg/kg genistein/day (150G) or genistein-free vehicle control (0G) for 1- or 2-weeks. Methods and Results: Injecting with 600G elicited significant increases in basal Isc in females after 1-week (ñ70 µA/cm2, n=15, p < 0.05) and in males after 2-weeks (ñ80 µA/cm2, n=5, p < 0.05) compared to their 0G counterparts. Chloride-free ringer significantly reduced basal Isc by 65% in 600G males and 72% in 600G females, suggesting that Cl- was the major anion comprising the genistein-stimulated secretion. The forskolin-stimulated (10 µM) Isc was significantly inhibited by the CFTR chloride channel inhibitors, glibenclamide (500 µM) and CFTRinh-172 (100 µM) in 600G males and females, suggesting some contribution by genistein-dependent CFTR-mediated Cl- secretion. We found no associated changes in intestinal morphology, nor change in total CFTR protein with 600G. There was a 5% increase in apical/subapical ratio in 600G males compared to controls (no change in females). Conclusion: These data suggest that male and female mice both exhibit increased Cl- secretion with 600G, however, the mechanisms mediating this are gender-dependent." @default.
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• W2034352587 date "2011-01-01" @default.
• W2034352587 modified "2023-10-14" @default.
• W2034352587 title "Stimulation of Murine Intestinal Secretion by Daily Genistein Injections: Gender-dependent Differences" @default.
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• W2034352587 doi "https://doi.org/10.1159/000331736" @default.
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