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• W2034353345 startingPage "5077" @default.
• W2034353345 abstract "In response to environmental stresses, Toxoplasma gondii induces a global translational repression which allows for the remodeling of its transcriptome. While some transcripts are preferentially translated, another subset is translationally repressed and maintained in bradyzoites. Although little is known of how transcripts are targeted for sustained translational repression, the targeting probably operates through an RNA ‐centric mechanism relying on the recognition of cis ‐acting elements. In this study, we sought to determine if the targeting of transcripts through recognizable cis ‐acting elements could be responsible for the transcript‐specific sustained translational repression displayed by Toxoplasma bradyzoites. We examined the UTR s of a translationally repressed gene, lactate dehydrogenase 1, and found a 40 nucleotide regulatory element in its 5′ UTR . This element specifically induces translational repression in otherwise constitutively expressed transcripts. Mutational studies revealed that the formation of a small 16 nucleotide regulatory RNA hairpin is essential for this activity. We suggest that this hairpin may act as the nucleation site for the binding of an as yet to be identified trans ‐acting factor that allows for the transcript to be targeted for translational repression removal from the active translational pool. To our knowledge, this is the first report characterizing a specific cis ‐acting element contributing to post‐transcriptional gene regulation in Toxoplasma and suggests the presence of a pathway by which the parasites can recognize, identify and specifically target transcripts for sustained translational repression under stressful conditions." @default.
• W2034353345 created "2016-06-24" @default.
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• W2034353345 date "2014-10-04" @default.
• W2034353345 modified "2023-10-18" @default.
• W2034353345 title "Sustained translational repression of lactate dehydrogenase 1 inToxoplasma gondiibradyzoites is conferred by a small regulatory RNA hairpin" @default.
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• W2034353345 doi "https://doi.org/10.1111/febs.13048" @default.
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