FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034354472> ?p ?o ?g. }

• W2034354472 endingPage "776" @default.
• W2034354472 startingPage "769" @default.
• W2034354472 abstract "Previously we proposed and provided evidence for the metabolic pathway of felbamate (FBM), which leads to the reactive metabolite, 3-carbamoyl-2-phenylpropion-aldehyde. This aldehyde carbamate was suggested to be the reactive intermediate in the oxidation of 2-phenyl-1,3-propanediol monocarbamate to the major human metabolite 3-carbamoyl-2-phenylpropionic acid. In addition, the aldehyde carbamate was found to undergo spontaneous elimination to 2-phenylpropenal, commonly known as atropaldehyde. Moreover, atropaldehyde was proposed to play a role in the development of toxicity during FBM therapy. Evidence for atropaldehyde formation in vivo was reported with the identification of modified N-acetyl-cysteine conjugates of atropaldehyde in both human and rat urine after FBM administration. Identification of the atropaldehyde-derived mercapturic acids in urine after FBM administration is consistent with the hypothesis that atropaldehyde is formed in vivo and that it reacts with thiol nucleophiles. Based on the hypothesis that the potential for toxicity will correlate to the amount of atropaldehyde formed, we sought to develop an analytic method that would quantify the amount of relevant metabolites excreted in patient urine.We summarize the results of an LC/MS method used to quantify FBM, 3-carbamoyl-2-phenylpropionic acid and two atropaldehyde-derived mercapturic acids in the patient population.Analysis was performed on 31 patients undergoing FBM therapy. The absolute quantities of FBM and three metabolites were measured.This method demonstrated sufficient precision for the identification of patients exhibiting abnormal levels of atropaldehyde conjugates and may hold potential for patient monitoring." @default.
• W2034354472 created "2016-06-24" @default.
• W2034354472 creator A5000300255 @default.
• W2034354472 creator A5002317532 @default.
• W2034354472 creator A5020841472 @default.
• W2034354472 creator A5047306591 @default.
• W2034354472 creator A5059057763 @default.
• W2034354472 creator A5062492941 @default.
• W2034354472 creator A5064555386 @default.
• W2034354472 creator A5071299290 @default.
• W2034354472 creator A5072174645 @default.
• W2034354472 creator A5081777872 @default.
• W2034354472 creator A5085037662 @default.
• W2034354472 date "1999-06-01" @default.
• W2034354472 modified "2023-10-06" @default.
• W2034354472 title "Quantification in Patient Urine Samples of Felbamate and Three Metabolites: Acid Carbamate and Two Mercapturic Acids" @default.
• W2034354472 cites W1966612438 @default.
• W2034354472 cites W2002533466 @default.
• W2034354472 cites W2008042616 @default.
• W2034354472 cites W2013331166 @default.
• W2034354472 cites W2020232933 @default.
• W2034354472 cites W2031632460 @default.
• W2034354472 cites W2037943114 @default.
• W2034354472 cites W2050005113 @default.
• W2034354472 cites W2066331200 @default.
• W2034354472 cites W2070123451 @default.
• W2034354472 cites W2076528505 @default.
• W2034354472 cites W2083291065 @default.
• W2034354472 cites W2106629607 @default.
• W2034354472 cites W2138812583 @default.
• W2034354472 cites W2143258645 @default.
• W2034354472 cites W4245090200 @default.
• W2034354472 doi "https://doi.org/10.1111/j.1528-1157.1999.tb00777.x" @default.
• W2034354472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10368077" @default.
• W2034354472 hasPublicationYear "1999" @default.
• W2034354472 type Work @default.
• W2034354472 sameAs 2034354472 @default.
• W2034354472 citedByCount "55" @default.
• W2034354472 countsByYear W20343544722012 @default.
• W2034354472 countsByYear W20343544722013 @default.
• W2034354472 countsByYear W20343544722014 @default.
• W2034354472 countsByYear W20343544722015 @default.
• W2034354472 countsByYear W20343544722016 @default.
• W2034354472 countsByYear W20343544722017 @default.
• W2034354472 countsByYear W20343544722019 @default.
• W2034354472 countsByYear W20343544722021 @default.
• W2034354472 countsByYear W20343544722022 @default.
• W2034354472 countsByYear W20343544722023 @default.
• W2034354472 crossrefType "journal-article" @default.
• W2034354472 hasAuthorship W2034354472A5000300255 @default.
• W2034354472 hasAuthorship W2034354472A5002317532 @default.
• W2034354472 hasAuthorship W2034354472A5020841472 @default.
• W2034354472 hasAuthorship W2034354472A5047306591 @default.
• W2034354472 hasAuthorship W2034354472A5059057763 @default.
• W2034354472 hasAuthorship W2034354472A5062492941 @default.
• W2034354472 hasAuthorship W2034354472A5064555386 @default.
• W2034354472 hasAuthorship W2034354472A5071299290 @default.
• W2034354472 hasAuthorship W2034354472A5072174645 @default.
• W2034354472 hasAuthorship W2034354472A5081777872 @default.
• W2034354472 hasAuthorship W2034354472A5085037662 @default.
• W2034354472 hasBestOaLocation W20343544721 @default.
• W2034354472 hasConcept C118552586 @default.
• W2034354472 hasConcept C150903083 @default.
• W2034354472 hasConcept C178790620 @default.
• W2034354472 hasConcept C179998833 @default.
• W2034354472 hasConcept C181199279 @default.
• W2034354472 hasConcept C185592680 @default.
• W2034354472 hasConcept C195289149 @default.
• W2034354472 hasConcept C207001950 @default.
• W2034354472 hasConcept C2775858608 @default.
• W2034354472 hasConcept C2776923573 @default.
• W2034354472 hasConcept C2777477808 @default.
• W2034354472 hasConcept C2778186239 @default.
• W2034354472 hasConcept C2779201268 @default.
• W2034354472 hasConcept C2779303437 @default.
• W2034354472 hasConcept C2780026642 @default.
• W2034354472 hasConcept C2780158455 @default.
• W2034354472 hasConcept C2780539824 @default.
• W2034354472 hasConcept C2781011581 @default.
• W2034354472 hasConcept C29730261 @default.
• W2034354472 hasConcept C43617362 @default.
• W2034354472 hasConcept C55493867 @default.
• W2034354472 hasConcept C62231903 @default.
• W2034354472 hasConcept C71924100 @default.
• W2034354472 hasConcept C86803240 @default.
• W2034354472 hasConcept C98274493 @default.
• W2034354472 hasConceptScore W2034354472C118552586 @default.
• W2034354472 hasConceptScore W2034354472C150903083 @default.
• W2034354472 hasConceptScore W2034354472C178790620 @default.
• W2034354472 hasConceptScore W2034354472C179998833 @default.
• W2034354472 hasConceptScore W2034354472C181199279 @default.
• W2034354472 hasConceptScore W2034354472C185592680 @default.
• W2034354472 hasConceptScore W2034354472C195289149 @default.
• W2034354472 hasConceptScore W2034354472C207001950 @default.
• W2034354472 hasConceptScore W2034354472C2775858608 @default.
• W2034354472 hasConceptScore W2034354472C2776923573 @default.
• W2034354472 hasConceptScore W2034354472C2777477808 @default.
• W2034354472 hasConceptScore W2034354472C2778186239 @default.

• next