FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034354773> ?p ?o ?g. }

• W2034354773 endingPage "58" @default.
• W2034354773 startingPage "51" @default.
• W2034354773 abstract "Mitochondria and the p38 mitogen-activated protein kinase (MAPK) pathways play important roles in apoptosis. Although the effect of bupivacaine on apoptosis is known, it remains unclear whether bupivacaine induces apoptosis via mitochondrial depolarization and the p38 MAPK activity. In this study, SH-SY5Y cells were pretreated respectively with 50μM 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS), 10μM 4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-5-(4-pyridyl)-1H-imidazole (SB203580), and 50μM DIDS plus 10μM SB203580 30min prior to the treatment with either 1mM bupivacaine or an equivalent amount of medium. The cell viability, mitochondrial membrane potential, phospho-p38 MAPK (p-p38 MAPK) and cell apoptosis were investigated with MTT assay, western blots, Hoechst 33258 staining and flow cytometry assay. In addition, the roles of chloridion (Cl(-)) channel and reactive oxygen species were studied to explore the molecular mechanism of bupivacaine-induced mitochondrial injury. Pretreatment with DIDS could attenuate reactive oxygen species production, the phosphorylation of p38MAPK, dissipation of mitochondrial membrane potential and apoptosis of SH-SY5Y cells induced by bupivacaine. Pretreatment with SB203580 could attenuate apoptosis, but could not attenuate reactive oxygen species production, or dissipation of mitochondrial membrane potential induced by bupivacaine. These findings indicate that the mitochondrial anion channel and p38 MAPK pathway are implicated in bupicavaine-induced apoptosis. Bupivacaine-induced reactive oxygen species production results in an alteration in the permeability of the mitochondrial membranes and Cl(-) influx into mitochondria, which seems to be responsible for mitochondrial depolarization and the p38 MAPK activation." @default.
• W2034354773 created "2016-06-24" @default.
• W2034354773 creator A5032982154 @default.
• W2034354773 creator A5033104756 @default.
• W2034354773 creator A5043943583 @default.
• W2034354773 creator A5076924695 @default.
• W2034354773 creator A5088144005 @default.
• W2034354773 date "2011-04-01" @default.
• W2034354773 modified "2023-09-25" @default.
• W2034354773 title "Bupivacaine induces apoptosis via mitochondria and p38 MAPK dependent pathways" @default.
• W2034354773 cites W1490306683 @default.
• W2034354773 cites W1963721113 @default.
• W2034354773 cites W1965017177 @default.
• W2034354773 cites W1976994092 @default.
• W2034354773 cites W1991791433 @default.
• W2034354773 cites W1992185401 @default.
• W2034354773 cites W1994737393 @default.
• W2034354773 cites W2000353746 @default.
• W2034354773 cites W2002186600 @default.
• W2034354773 cites W2005346853 @default.
• W2034354773 cites W2010845266 @default.
• W2034354773 cites W2015221597 @default.
• W2034354773 cites W2028434053 @default.
• W2034354773 cites W2030683324 @default.
• W2034354773 cites W2032459598 @default.
• W2034354773 cites W2036453111 @default.
• W2034354773 cites W2050010146 @default.
• W2034354773 cites W2061711733 @default.
• W2034354773 cites W2062959330 @default.
• W2034354773 cites W2084365684 @default.
• W2034354773 cites W2089537636 @default.
• W2034354773 cites W2091189172 @default.
• W2034354773 cites W2092732744 @default.
• W2034354773 cites W2106414994 @default.
• W2034354773 cites W2135314348 @default.
• W2034354773 cites W2148230219 @default.
• W2034354773 cites W2323116854 @default.
• W2034354773 doi "https://doi.org/10.1016/j.ejphar.2011.01.055" @default.
• W2034354773 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21315711" @default.
• W2034354773 hasPublicationYear "2011" @default.
• W2034354773 type Work @default.
• W2034354773 sameAs 2034354773 @default.
• W2034354773 citedByCount "47" @default.
• W2034354773 countsByYear W20343547732012 @default.
• W2034354773 countsByYear W20343547732013 @default.
• W2034354773 countsByYear W20343547732014 @default.
• W2034354773 countsByYear W20343547732015 @default.
• W2034354773 countsByYear W20343547732016 @default.
• W2034354773 countsByYear W20343547732017 @default.
• W2034354773 countsByYear W20343547732018 @default.
• W2034354773 countsByYear W20343547732019 @default.
• W2034354773 countsByYear W20343547732020 @default.
• W2034354773 countsByYear W20343547732021 @default.
• W2034354773 countsByYear W20343547732022 @default.
• W2034354773 countsByYear W20343547732023 @default.
• W2034354773 crossrefType "journal-article" @default.
• W2034354773 hasAuthorship W2034354773A5032982154 @default.
• W2034354773 hasAuthorship W2034354773A5033104756 @default.
• W2034354773 hasAuthorship W2034354773A5043943583 @default.
• W2034354773 hasAuthorship W2034354773A5076924695 @default.
• W2034354773 hasAuthorship W2034354773A5088144005 @default.
• W2034354773 hasConcept C153911025 @default.
• W2034354773 hasConcept C173358068 @default.
• W2034354773 hasConcept C181911157 @default.
• W2034354773 hasConcept C184235292 @default.
• W2034354773 hasConcept C185592680 @default.
• W2034354773 hasConcept C190283241 @default.
• W2034354773 hasConcept C2779533339 @default.
• W2034354773 hasConcept C28859421 @default.
• W2034354773 hasConcept C41625074 @default.
• W2034354773 hasConcept C48349386 @default.
• W2034354773 hasConcept C51551487 @default.
• W2034354773 hasConcept C55493867 @default.
• W2034354773 hasConcept C57074206 @default.
• W2034354773 hasConcept C75385678 @default.
• W2034354773 hasConcept C86803240 @default.
• W2034354773 hasConcept C95444343 @default.
• W2034354773 hasConceptScore W2034354773C153911025 @default.
• W2034354773 hasConceptScore W2034354773C173358068 @default.
• W2034354773 hasConceptScore W2034354773C181911157 @default.
• W2034354773 hasConceptScore W2034354773C184235292 @default.
• W2034354773 hasConceptScore W2034354773C185592680 @default.
• W2034354773 hasConceptScore W2034354773C190283241 @default.
• W2034354773 hasConceptScore W2034354773C2779533339 @default.
• W2034354773 hasConceptScore W2034354773C28859421 @default.
• W2034354773 hasConceptScore W2034354773C41625074 @default.
• W2034354773 hasConceptScore W2034354773C48349386 @default.
• W2034354773 hasConceptScore W2034354773C51551487 @default.
• W2034354773 hasConceptScore W2034354773C55493867 @default.
• W2034354773 hasConceptScore W2034354773C57074206 @default.
• W2034354773 hasConceptScore W2034354773C75385678 @default.
• W2034354773 hasConceptScore W2034354773C86803240 @default.
• W2034354773 hasConceptScore W2034354773C95444343 @default.
• W2034354773 hasIssue "1-3" @default.
• W2034354773 hasLocation W20343547731 @default.
• W2034354773 hasLocation W20343547732 @default.
• W2034354773 hasOpenAccess W2034354773 @default.
• W2034354773 hasPrimaryLocation W20343547731 @default.

• next