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• W2034356684 endingPage "5534" @default.
• W2034356684 startingPage "5515" @default.
• W2034356684 abstract "No cure as of yet exists for any of the transmissible spongiform encephalopathies. In this paper, we describe the synthesis of analogues of Congo red and evaluation against a cellular model of infection, the SMB (scrapie mouse brain) persistently infected cell line, for their ability to inhibit the infectivity of the abnormal form of prion protein (PrP-res). The compounds have also been tested for their ability to inhibit the polymerization of PrPC by PrP-res. A number of analogues showed inhibition of PrP-res infectivity at nanomolar concentrations. Several analogues show promise; the most active compound, 2a, inhibits the formation of PrP-res in SMB cells with an EC50 of 25-50 nM." @default.
• W2034356684 created "2016-06-24" @default.
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• W2034356684 date "2004-09-29" @default.
• W2034356684 modified "2023-10-18" @default.
• W2034356684 title "Synthesis of Analogues of Congo Red and Evaluation of Their Anti-Prion Activity" @default.
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• W2034356684 doi "https://doi.org/10.1021/jm049922t" @default.
• W2034356684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15481988" @default.
• W2034356684 hasPublicationYear "2004" @default.
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