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• W2034356701 abstract "Lysyl oxidase catalyzes the oxidation of peptidyl lysine to alpha-aminoadipic-delta-semialdehyde, the precursor to the covalent crosslinkages that stabilize fibers of elastin and collagen. This enzyme contains both copper and a carbonyl cofactor consistent with an o-quinone. The proposed mechanism of action is derived from available kinetic and chemical data and also can account for mechanism-based inhibition of the enzyme by specific monoamines and diamines. Recent evidence for biosynthetic precursors and for the regulation of lysyl oxidase in fibrotic and malignant diseases is discussed." @default.
• W2034356701 created "2016-06-24" @default.
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• W2034356701 date "1991-09-01" @default.
• W2034356701 modified "2023-10-14" @default.
• W2034356701 title "Properties and Function of Lysyl Oxidase" @default.
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• W2034356701 doi "https://doi.org/10.1165/ajrcmb/5.3.206" @default.
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