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- W2034358142 abstract "Studies of chromosomal losses at 17p13 have suggested the presence of at least two distinct regions for tumor suppressor genes, the TP53 region at 17p13.1 and a more distal region at 17p13.3. Within the latter region, Hypermethylated in Cancer 1 (HIC1) is located, a likely candidate for a tumor suppressor gene that has also been suggested to play a role in the pathogenesis of Miller-Diecker syndrome (MDS). However, single-gene isolation efforts have retrieved additional genes from 17p13.3 that could play a role in tumorigenesis. This indicates that the full potential of this chromosomal region with respect to disease-related genes has not yet been exhausted and that there may exist still unknown genes that contribute to tumorigenesis or to the complex MDS phenotype. To provide a basis for the systematic isolation and evaluation of such genes, we established a physical map over 1.5 Mb of 17p13.3 and assigned 29 transcriptional units within this region." @default.
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- W2034358142 date "2000-11-01" @default.
- W2034358142 modified "2023-09-26" @default.
- W2034358142 title "Physical and Transcriptional Mapping of the 17p13.3 Region That Is Frequently Deleted in Human Cancer" @default.
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- W2034358142 doi "https://doi.org/10.1006/geno.2000.6353" @default.
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