FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034360085> ?p ?o ?g. }

• W2034360085 endingPage "50" @default.
• W2034360085 startingPage "40" @default.
• W2034360085 abstract "Public water fluoridation is a common policy for improving dental health. Fluoride replaces the hydroxyls of hydroxyapatite, thereby improving the strength of tooth enamel, but this process can also occur in other active calcifications. This paper studies the effects of water fluoridation during the course of vascular calcification in renal disease. The effect of fluoride was studied in vitro and in vivo. Rat aortic smooth muscle cells were calcified with 2 mM Pi for 5 days. Fluoride concentrations of 5–10 μM – similar to those found in people who drink fluoridated water – partially prevented calcification, death, and osteogene expression in vitro. The anticalcifying mechanism was independent of cell activity, matrix Gla protein, and fetuin A expressions, and it exhibited an IC50 of 8.7 μM fluoride. In vivo, however, fluoridation of drinking water at 1.5 mg/L (concentration recommended by the WHO) and 15 mg/L dramatically increased the incipient aortic calcification observed in rats with experimental chronic kidney disease (CKD, 5/6-nephrectomy), fed a Pi-rich fodder (1.2% Pi). Fluoride further declined the remaining renal function of the CKD animals, an effect that most likely overwhelmed the positive effect of fluoride on calcification in vitro. Ultrastructural analysis revealed that fluoride did not modify the Ca/P atomic ratio, but it was incorporated into the lattice of in vivo deposits. Fluoride also converted the crystallization pattern from plate to rode-like structures. In conclusion, while fluoride prevents calcification in vitro, the WHO's recommended concentrations in drinking water become nephrotoxic to CKD rats, thereby aggravating renal disease and making media vascular calcification significant." @default.
• W2034360085 created "2016-06-24" @default.
• W2034360085 creator A5006242222 @default.
• W2034360085 creator A5019028180 @default.
• W2034360085 creator A5057244396 @default.
• W2034360085 creator A5065063649 @default.
• W2034360085 date "2014-04-01" @default.
• W2034360085 modified "2023-10-02" @default.
• W2034360085 title "Effect of water fluoridation on the development of medial vascular calcification in uremic rats" @default.
• W2034360085 cites W121634664 @default.
• W2034360085 cites W1577720241 @default.
• W2034360085 cites W1583849740 @default.
• W2034360085 cites W1963553459 @default.
• W2034360085 cites W1978271794 @default.
• W2034360085 cites W1984375217 @default.
• W2034360085 cites W1990908026 @default.
• W2034360085 cites W2007488057 @default.
• W2034360085 cites W2007666320 @default.
• W2034360085 cites W2008893552 @default.
• W2034360085 cites W2011039465 @default.
• W2034360085 cites W2021222148 @default.
• W2034360085 cites W2023340750 @default.
• W2034360085 cites W2029665941 @default.
• W2034360085 cites W2040124153 @default.
• W2034360085 cites W2049410848 @default.
• W2034360085 cites W2056462245 @default.
• W2034360085 cites W2061128416 @default.
• W2034360085 cites W2065070581 @default.
• W2034360085 cites W2072196650 @default.
• W2034360085 cites W2072267584 @default.
• W2034360085 cites W2072500900 @default.
• W2034360085 cites W2086000802 @default.
• W2034360085 cites W2108116509 @default.
• W2034360085 cites W2116673160 @default.
• W2034360085 cites W2139636433 @default.
• W2034360085 cites W2144565447 @default.
• W2034360085 cites W2147700211 @default.
• W2034360085 cites W2149833693 @default.
• W2034360085 cites W2152509315 @default.
• W2034360085 cites W2152792847 @default.
• W2034360085 cites W2153838822 @default.
• W2034360085 cites W2164038572 @default.
• W2034360085 cites W2166199725 @default.
• W2034360085 cites W2488013397 @default.
• W2034360085 cites W4245692786 @default.
• W2034360085 doi "https://doi.org/10.1016/j.tox.2014.01.012" @default.
• W2034360085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24561004" @default.
• W2034360085 hasPublicationYear "2014" @default.
• W2034360085 type Work @default.
• W2034360085 sameAs 2034360085 @default.
• W2034360085 citedByCount "11" @default.
• W2034360085 countsByYear W20343600852014 @default.
• W2034360085 countsByYear W20343600852015 @default.
• W2034360085 countsByYear W20343600852017 @default.
• W2034360085 countsByYear W20343600852020 @default.
• W2034360085 countsByYear W20343600852021 @default.
• W2034360085 countsByYear W20343600852022 @default.
• W2034360085 countsByYear W20343600852023 @default.
• W2034360085 crossrefType "journal-article" @default.
• W2034360085 hasAuthorship W2034360085A5006242222 @default.
• W2034360085 hasAuthorship W2034360085A5019028180 @default.
• W2034360085 hasAuthorship W2034360085A5057244396 @default.
• W2034360085 hasAuthorship W2034360085A5065063649 @default.
• W2034360085 hasConcept C126189478 @default.
• W2034360085 hasConcept C126322002 @default.
• W2034360085 hasConcept C134018914 @default.
• W2034360085 hasConcept C150903083 @default.
• W2034360085 hasConcept C179104552 @default.
• W2034360085 hasConcept C185592680 @default.
• W2034360085 hasConcept C199343813 @default.
• W2034360085 hasConcept C207001950 @default.
• W2034360085 hasConcept C2778653478 @default.
• W2034360085 hasConcept C2779097656 @default.
• W2034360085 hasConcept C2780091579 @default.
• W2034360085 hasConcept C2780309369 @default.
• W2034360085 hasConcept C2780828025 @default.
• W2034360085 hasConcept C71924100 @default.
• W2034360085 hasConcept C86803240 @default.
• W2034360085 hasConceptScore W2034360085C126189478 @default.
• W2034360085 hasConceptScore W2034360085C126322002 @default.
• W2034360085 hasConceptScore W2034360085C134018914 @default.
• W2034360085 hasConceptScore W2034360085C150903083 @default.
• W2034360085 hasConceptScore W2034360085C179104552 @default.
• W2034360085 hasConceptScore W2034360085C185592680 @default.
• W2034360085 hasConceptScore W2034360085C199343813 @default.
• W2034360085 hasConceptScore W2034360085C207001950 @default.
• W2034360085 hasConceptScore W2034360085C2778653478 @default.
• W2034360085 hasConceptScore W2034360085C2779097656 @default.
• W2034360085 hasConceptScore W2034360085C2780091579 @default.
• W2034360085 hasConceptScore W2034360085C2780309369 @default.
• W2034360085 hasConceptScore W2034360085C2780828025 @default.
• W2034360085 hasConceptScore W2034360085C71924100 @default.
• W2034360085 hasConceptScore W2034360085C86803240 @default.
• W2034360085 hasLocation W20343600851 @default.
• W2034360085 hasLocation W20343600852 @default.
• W2034360085 hasOpenAccess W2034360085 @default.
• W2034360085 hasPrimaryLocation W20343600851 @default.
• W2034360085 hasRelatedWork W2042033030 @default.

• next