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• W2034360108 abstract "We identify the interfollicular (IF) zone as the site where germinal center B cell and T follicular helper (Tfh) cell differentiation initiates. For the first 2 days postimmunization, antigen-specific T and B cells remained confined within the IF zone, formed long-lived interactions, and upregulated the transcriptional repressor Bcl6. T cells also acquired the Tfh cell markers CXCR5, PD-1, and GL7. Responding B and T cells migrated to the follicle interior directly from the IF zone, T cell immigration preceding B cells by 1 day. Notably, in the absence of cognate B cells, Tfh cells still formed and migrated to the follicle. However, without such B cells, PD-1, ICOS, and GL7 were no longer expressed on follicular Bcl6(hi) T cells that nevertheless persisted in the follicle. Thus, Ag-specific B cells are required for the maintenance of the PD-1(hi)ICOS(hi)GL7(hi) Tfh cell phenotype within the follicle, but not for their initial differentiation in the IF zone." @default.
• W2034360108 created "2016-06-24" @default.
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• W2034360108 date "2011-06-01" @default.
• W2034360108 modified "2023-10-16" @default.
• W2034360108 title "Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone" @default.
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• W2034360108 doi "https://doi.org/10.1016/j.immuni.2011.03.024" @default.
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