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- W2034361540 abstract "mAbs account for an increasing portion of marketed human biological therapeutics. As a consequence, the importance of optimal selection, design, and engineering of these not only has expanded in the past 2 decades but also is now coming into play as a competitive factor. This review delineates the 4 basic areas for optimal therapeutic antibody selection and provides examples of the increasing number of considerations necessary for, and options available for, antibody design. Though some of the advances in antibody technology (eg, antibodies derived from phage-display libraries) have already made it to market, other more recent advances, such as engineering antibodies for enhanced effector functions, may not be far behind, especially given the increasing competition for therapeutic antibodies to the same target (eg, anti-CD20 and anti-TNF-alpha)." @default.
- W2034361540 created "2016-06-24" @default.
- W2034361540 creator A5049237460 @default.
- W2034361540 date "2005-10-01" @default.
- W2034361540 modified "2023-09-26" @default.
- W2034361540 title "Selection, design, and engineering of therapeutic antibodies" @default.
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- W2034361540 doi "https://doi.org/10.1016/j.jaci.2005.08.003" @default.
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