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- W2034362431 abstract "Substances that increase intracellular calcium ([Ca2+]i), such as potassium chloride and serotonin, are known to induce vascular smooth muscle (VSM) contraction. One form of nitric oxide synthase, which converts L-arginine to nitric oxide, exists as a Ca(2+)-calmodulin dependent enzyme. The objective of this study was to determine whether agonists that induce VSM contraction by increasing [Ca2+]i might also activate Ca(2+)-calmodulin dependent nitric oxide synthase in VSM.Strips of bovine carotid arterial smooth muscle denuded of endothelium were equilibrated in a physiologic muscle bath. A maximal contractile response to high extracellular potassium chloride and serotonin was established. The strips were then preincubated with NG-monomethyl-L-arginine (L-NMMA), a structural analog of L-arginine and specific inhibitor of nitric oxide synthase, and again treated with either KCl or 5-hydroxytryptamine.The contractile responses of muscle strips to KCl or 5-hydroxytryptamine were significantly greater in muscle strips pretreated with L-NMMA than responses in the absence of L-NMMA (p < 0.02, Student's t test). To determine whether this response was Ca2+ dependent, phorbolester-induced contractions in Ca(2+)-free conditions were examined. No difference was noted in the magnitude of Ca(2+)-free, phorbol ester-induced contractions in the presence and absence of L-NMMA.These data thus suggest that Ca(2+)-calmodulin dependent nitric oxide synthase is functionally present in VSM and may function as an autocrine regulatory mechanism of VSM contraction." @default.
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- W2034362431 date "1996-01-01" @default.
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- W2034362431 title "Nitric oxide is an autocrine feedback inhibitor of vascular smooth muscle contraction" @default.
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- W2034362431 doi "https://doi.org/10.1016/s0039-6060(96)80221-2" @default.
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