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- W2034363409 abstract "The purpose of our study was to assess the influence of lactation stage–dependent differences in milk-to-serum (M/S) ratio for an actively transported drug (cefepime) on the calculation of 2 exposure indices, EI Dose and EI Conc . Age-dependent differences in cefepime pharmacokinetics at postnatal days 4 and 10 as well as cefepime M/S values at lactation days 4 and 10 in rats were determined. Significantly higher elimination rate constant and systemic clearance and lower half-life were found in day 10 compared to day 4 pups with no differences in oral bioavailability. The EI Conc was quantitatively higher than EI Dose at both lactation stages. The ~7-fold decrease in cefepime M/S values at lactation day 10 resulted in ~7-fold reduction in the EI Dose and ~13-fold reduction in EI Conc . Our study confirms the need to evaluate M/S at different lactation stages for actively transported drugs to avoid over- or underestimation of neonatal exposure risk." @default.
- W2034363409 created "2016-06-24" @default.
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- W2034363409 date "2010-05-10" @default.
- W2034363409 modified "2023-09-27" @default.
- W2034363409 title "Lactation Stage Influences Drug Milk-to-Serum Values and Neonatal Exposure Risk" @default.
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- W2034363409 doi "https://doi.org/10.1177/1091581810367949" @default.
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