FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034363816> ?p ?o ?g. }

• W2034363816 endingPage "487" @default.
• W2034363816 startingPage "479" @default.
• W2034363816 abstract "A micromanipulation method is used to determine the adhesive energy density (gamma) between pairs of cytotoxic T cells (F1) and their target cells (JY: HLA-A2-B7-DR4,W6). gamma is defined as the energy per unit area that must be supplied to reduce the region of contact between a conjugated cell pair. Our analysis of the data indicates that the force applied by the micropipette on the cell is not uniformly distributed throughout the contact region as we had previously assumed (Sung, K. L. P., L. A. Sung, M. Crimmins, S. J. Burakoff, and S. Chien. 1986. Science (Wash. DC). 234: 1405-1408), but acts only at the edges of the contact region. We show that gamma is not constant during peeling but increases with decreasing contact area of the conjugated cell pairs F1-JY, F1-F1, and JY-JY in contrast to the constancy of gamma for typical engineering adhesives. This finding supports the notion that the cross-linking protein molecules slide towards the conjugated area across the leading edge of the separation while remaining attached to both cells. Our mathematical analysis shows that the elastic energy stored in the cross-links by the membrane tensions balances the diffusive forces that act against cross-bridge migration. The binding affinity between F1-JY is found to be approximately 15-20 times larger than the corresponding affinity for F1-F1. The number of binding sites of F1 for attachment to JY is approximately the same for binding F1 to another F1 and vary between 10(5) and 10(6)." @default.
• W2034363816 created "2016-06-24" @default.
• W2034363816 creator A5027675388 @default.
• W2034363816 creator A5055266606 @default.
• W2034363816 creator A5068335042 @default.
• W2034363816 date "1989-03-01" @default.
• W2034363816 modified "2023-09-26" @default.
• W2034363816 title "Theoretical and experimental studies on cross-bridge migration during cell disaggregation" @default.
• W2034363816 cites W1685470201 @default.
• W2034363816 cites W1964075877 @default.
• W2034363816 cites W1965337436 @default.
• W2034363816 cites W1985905499 @default.
• W2034363816 cites W1988893861 @default.
• W2034363816 cites W1993971815 @default.
• W2034363816 cites W2016323743 @default.
• W2034363816 cites W2017934591 @default.
• W2034363816 cites W2030181238 @default.
• W2034363816 cites W2031159210 @default.
• W2034363816 cites W2052192720 @default.
• W2034363816 cites W2053550995 @default.
• W2034363816 cites W2071417368 @default.
• W2034363816 cites W2073093121 @default.
• W2034363816 cites W2075974871 @default.
• W2034363816 cites W2078755593 @default.
• W2034363816 cites W2079529151 @default.
• W2034363816 cites W2080470647 @default.
• W2034363816 cites W2088583244 @default.
• W2034363816 cites W2089660778 @default.
• W2034363816 cites W2090472626 @default.
• W2034363816 cites W2113452409 @default.
• W2034363816 cites W2164238399 @default.
• W2034363816 cites W2164407523 @default.
• W2034363816 cites W789458867 @default.
• W2034363816 doi "https://doi.org/10.1016/s0006-3495(89)82841-3" @default.
• W2034363816 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1330501" @default.
• W2034363816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2784694" @default.
• W2034363816 hasPublicationYear "1989" @default.
• W2034363816 type Work @default.
• W2034363816 sameAs 2034363816 @default.
• W2034363816 citedByCount "79" @default.
• W2034363816 countsByYear W20343638162012 @default.
• W2034363816 countsByYear W20343638162013 @default.
• W2034363816 countsByYear W20343638162014 @default.
• W2034363816 countsByYear W20343638162015 @default.
• W2034363816 countsByYear W20343638162016 @default.
• W2034363816 countsByYear W20343638162017 @default.
• W2034363816 countsByYear W20343638162018 @default.
• W2034363816 countsByYear W20343638162019 @default.
• W2034363816 countsByYear W20343638162020 @default.
• W2034363816 countsByYear W20343638162021 @default.
• W2034363816 countsByYear W20343638162022 @default.
• W2034363816 crossrefType "journal-article" @default.
• W2034363816 hasAuthorship W2034363816A5027675388 @default.
• W2034363816 hasAuthorship W2034363816A5055266606 @default.
• W2034363816 hasAuthorship W2034363816A5068335042 @default.
• W2034363816 hasBestOaLocation W20343638161 @default.
• W2034363816 hasConcept C112613896 @default.
• W2034363816 hasConcept C12554922 @default.
• W2034363816 hasConcept C127413603 @default.
• W2034363816 hasConcept C162307627 @default.
• W2034363816 hasConcept C171250308 @default.
• W2034363816 hasConcept C178790620 @default.
• W2034363816 hasConcept C185592680 @default.
• W2034363816 hasConcept C192562407 @default.
• W2034363816 hasConcept C2779227376 @default.
• W2034363816 hasConcept C521977710 @default.
• W2034363816 hasConcept C68928338 @default.
• W2034363816 hasConcept C76155785 @default.
• W2034363816 hasConcept C8010536 @default.
• W2034363816 hasConcept C86803240 @default.
• W2034363816 hasConceptScore W2034363816C112613896 @default.
• W2034363816 hasConceptScore W2034363816C12554922 @default.
• W2034363816 hasConceptScore W2034363816C127413603 @default.
• W2034363816 hasConceptScore W2034363816C162307627 @default.
• W2034363816 hasConceptScore W2034363816C171250308 @default.
• W2034363816 hasConceptScore W2034363816C178790620 @default.
• W2034363816 hasConceptScore W2034363816C185592680 @default.
• W2034363816 hasConceptScore W2034363816C192562407 @default.
• W2034363816 hasConceptScore W2034363816C2779227376 @default.
• W2034363816 hasConceptScore W2034363816C521977710 @default.
• W2034363816 hasConceptScore W2034363816C68928338 @default.
• W2034363816 hasConceptScore W2034363816C76155785 @default.
• W2034363816 hasConceptScore W2034363816C8010536 @default.
• W2034363816 hasConceptScore W2034363816C86803240 @default.
• W2034363816 hasIssue "3" @default.
• W2034363816 hasLocation W20343638161 @default.
• W2034363816 hasLocation W20343638162 @default.
• W2034363816 hasLocation W20343638163 @default.
• W2034363816 hasLocation W20343638164 @default.
• W2034363816 hasOpenAccess W2034363816 @default.
• W2034363816 hasPrimaryLocation W20343638161 @default.
• W2034363816 hasRelatedWork W1986049138 @default.
• W2034363816 hasRelatedWork W2007164458 @default.
• W2034363816 hasRelatedWork W2008354382 @default.
• W2034363816 hasRelatedWork W2022224243 @default.
• W2034363816 hasRelatedWork W2075198971 @default.
• W2034363816 hasRelatedWork W2346698954 @default.
• W2034363816 hasRelatedWork W2402394151 @default.

• next