FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034366812> ?p ?o ?g. }

• W2034366812 endingPage "478" @default.
• W2034366812 startingPage "468" @default.
• W2034366812 abstract "Vascular dysfunction in atherosclerosis and diabetes mellitus, as observed in the aging population of developed societies, is associated with vascular DNA damage and cell senescence. We hypothesized that cumulative DNA damage during aging contributes to vascular dysfunction.In mice with genomic instability resulting from the defective nucleotide excision repair genes ERCC1 and XPD (Ercc1(d/-) and Xpd(TTD) mice), we explored age-dependent vascular function compared with that in wild-type mice. Ercc1(d/-) mice showed increased vascular cell senescence, accelerated development of vasodilator dysfunction, increased vascular stiffness, and elevated blood pressure at a very young age. The vasodilator dysfunction was due to decreased endothelial nitric oxide synthase levels and impaired smooth muscle cell function, which involved phosphodiesterase activity. Similar to Ercc1(d/-) mice, age-related endothelium-dependent vasodilator dysfunction in Xpd(TTD) animals was increased. To investigate the implications for human vascular disease, we explored associations between single-nucleotide polymorphisms of selected nucleotide excision repair genes and arterial stiffness within the AortaGen Consortium and found a significant association of a single-nucleotide polymorphism (rs2029298) in the putative promoter region of DDB2 gene with carotid-femoral pulse wave velocity.Mice with genomic instability recapitulate age-dependent vascular dysfunction as observed in animal models and in humans but with an accelerated progression compared with wild-type mice. In addition, we found associations between variations in human DNA repair genes and markers for vascular stiffness, which is associated with aging. Our study supports the concept that genomic instability contributes importantly to the development of cardiovascular disease." @default.
• W2034366812 created "2016-06-24" @default.
• W2034366812 creator A5004870117 @default.
• W2034366812 creator A5006192395 @default.
• W2034366812 creator A5011329367 @default.
• W2034366812 creator A5015385391 @default.
• W2034366812 creator A5016204107 @default.
• W2034366812 creator A5016771152 @default.
• W2034366812 creator A5017009749 @default.
• W2034366812 creator A5020686400 @default.
• W2034366812 creator A5030127774 @default.
• W2034366812 creator A5031530236 @default.
• W2034366812 creator A5034547016 @default.
• W2034366812 creator A5039611937 @default.
• W2034366812 creator A5043840964 @default.
• W2034366812 creator A5045503519 @default.
• W2034366812 creator A5046295598 @default.
• W2034366812 creator A5050153201 @default.
• W2034366812 creator A5050328866 @default.
• W2034366812 creator A5052209499 @default.
• W2034366812 creator A5052290354 @default.
• W2034366812 creator A5055433188 @default.
• W2034366812 creator A5060852803 @default.
• W2034366812 creator A5061668792 @default.
• W2034366812 creator A5066703087 @default.
• W2034366812 creator A5067633360 @default.
• W2034366812 creator A5068004396 @default.
• W2034366812 creator A5071456578 @default.
• W2034366812 creator A5072053749 @default.
• W2034366812 creator A5073047383 @default.
• W2034366812 creator A5077045914 @default.
• W2034366812 creator A5080967707 @default.
• W2034366812 creator A5090277687 @default.
• W2034366812 creator A5091173895 @default.
• W2034366812 date "2012-07-24" @default.
• W2034366812 modified "2023-10-17" @default.
• W2034366812 title "Nucleotide Excision DNA Repair Is Associated With Age-Related Vascular Dysfunction" @default.
• W2034366812 cites W1559904992 @default.
• W2034366812 cites W1978892849 @default.
• W2034366812 cites W1981148605 @default.
• W2034366812 cites W1982584549 @default.
• W2034366812 cites W1982602899 @default.
• W2034366812 cites W1988559818 @default.
• W2034366812 cites W2009124426 @default.
• W2034366812 cites W2021128415 @default.
• W2034366812 cites W2038273086 @default.
• W2034366812 cites W2043355615 @default.
• W2034366812 cites W2071897748 @default.
• W2034366812 cites W2074052803 @default.
• W2034366812 cites W2080605611 @default.
• W2034366812 cites W2084691868 @default.
• W2034366812 cites W2085990944 @default.
• W2034366812 cites W2095957083 @default.
• W2034366812 cites W2097943011 @default.
• W2034366812 cites W2098534438 @default.
• W2034366812 cites W2101214961 @default.
• W2034366812 cites W2108106334 @default.
• W2034366812 cites W2114171855 @default.
• W2034366812 cites W2119545067 @default.
• W2034366812 cites W2127395181 @default.
• W2034366812 cites W2127903162 @default.
• W2034366812 cites W2127996877 @default.
• W2034366812 cites W2135369607 @default.
• W2034366812 cites W2136482074 @default.
• W2034366812 cites W2147671485 @default.
• W2034366812 cites W2155554546 @default.
• W2034366812 cites W2159094171 @default.
• W2034366812 cites W2165304530 @default.
• W2034366812 cites W3015544325 @default.
• W2034366812 cites W4256530495 @default.
• W2034366812 doi "https://doi.org/10.1161/circulationaha.112.104380" @default.
• W2034366812 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3430727" @default.
• W2034366812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22705887" @default.
• W2034366812 hasPublicationYear "2012" @default.
• W2034366812 type Work @default.
• W2034366812 sameAs 2034366812 @default.
• W2034366812 citedByCount "147" @default.
• W2034366812 countsByYear W20343668122012 @default.
• W2034366812 countsByYear W20343668122013 @default.
• W2034366812 countsByYear W20343668122014 @default.
• W2034366812 countsByYear W20343668122015 @default.
• W2034366812 countsByYear W20343668122016 @default.
• W2034366812 countsByYear W20343668122017 @default.
• W2034366812 countsByYear W20343668122018 @default.
• W2034366812 countsByYear W20343668122019 @default.
• W2034366812 countsByYear W20343668122020 @default.
• W2034366812 countsByYear W20343668122021 @default.
• W2034366812 countsByYear W20343668122022 @default.
• W2034366812 countsByYear W20343668122023 @default.
• W2034366812 crossrefType "journal-article" @default.
• W2034366812 hasAuthorship W2034366812A5004870117 @default.
• W2034366812 hasAuthorship W2034366812A5006192395 @default.
• W2034366812 hasAuthorship W2034366812A5011329367 @default.
• W2034366812 hasAuthorship W2034366812A5015385391 @default.
• W2034366812 hasAuthorship W2034366812A5016204107 @default.
• W2034366812 hasAuthorship W2034366812A5016771152 @default.
• W2034366812 hasAuthorship W2034366812A5017009749 @default.
• W2034366812 hasAuthorship W2034366812A5020686400 @default.

• next