FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034367257> ?p ?o ?g. }

• W2034367257 endingPage "21" @default.
• W2034367257 startingPage "15" @default.
• W2034367257 abstract "Four multicentre trials have investigated the efficacy and tolerability of treatment with once-daily, modified-release capsules of barnidipine, a long-acting dihydropyridine calcium antagonist, in patients with mild to moderate essential hypertension. In two of these trials, the clinical profile of barnidipine was compared with those of amlodipine and nitrendipine, which belong to the same class of drug as barnidipine, in a randomized, double-blind, parallel-group manner. In one study, 37 patients received amlodipine and 79 patients received barnidipine. In a second study, 46 patients received nitrendipine and 96 received barnidipine. In each trial, a 4-week placebo run-in phase was followed by a 12-week comparative phase. Changes in sitting and standing diastolic and systolic blood pressures were assessed, and adverse events were recorded. Both studies demonstrated that the antihypertensive efficacy of barnidipine was equivalent to each comparator agent, but barnidipine tended to produce fewer class I adverse reactions. The long-term efficacy and safety of barnidipine were demonstrated in an open-label study. In total, 106 patients were followed for the first year of the study, during which time they received barnidipine at a dose titrated to achieve a sitting diastolic blood pressure of less than 90 mm Hg; if necessary, another antihypertensive agent was added to achieve normalization of blood pressure. Seventy-nine of these patients, most of whom were maintained on barnidipine monotherapy, were followed for a second year, and 32 patients, all of whom received barnidipine monotherapy throughout the study period, were followed for a third year. Blood pressure normalization after 1 year of follow-up was achieved in 91% of patients, and was maintained for the second and third years in 91% and 81% of patients, respectively. The incidence of adverse events, possibly or probably attributable to barnidipine, was 22%, 14% and 3%, respectively, during each successive year. The suitability of barnidipine for once-daily dosing was confirmed in a randomized, double-blind, placebo-controlled, crossover study of 20 patients. These patients were given 6-week regimens of both barnidipine (20 mg) and placebo, preceding 24-h ambulatory blood pressure monitoring. Barnidipine lowered blood pressure to a significantly greater extent than placebo both at night and during the day. These studies suggest that barnidipine possesses equivalent efficacy to amlodipine and nitrendipine, but produces fewer class-specific side-effects. It provides 24-h efficacy from a once-daily dosing regimen, and this efficacy and its safety profile are maintained for at least 3 years." @default.
• W2034367257 created "2016-06-24" @default.
• W2034367257 creator A5081242214 @default.
• W2034367257 date "1998-01-01" @default.
• W2034367257 modified "2023-10-16" @default.
• W2034367257 title "Efficacy and Tolerability of Once-daily Barnidipine in the Clinical Management of Patients with Mild to Moderate Essential Hypertension" @default.
• W2034367257 cites W1972458471 @default.
• W2034367257 cites W2022264052 @default.
• W2034367257 cites W2114634962 @default.
• W2034367257 cites W2416538760 @default.
• W2034367257 cites W4235430003 @default.
• W2034367257 doi "https://doi.org/10.1080/080370598438555" @default.
• W2034367257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9660522" @default.
• W2034367257 hasPublicationYear "1998" @default.
• W2034367257 type Work @default.
• W2034367257 sameAs 2034367257 @default.
• W2034367257 citedByCount "14" @default.
• W2034367257 countsByYear W20343672572015 @default.
• W2034367257 countsByYear W20343672572017 @default.
• W2034367257 crossrefType "journal-article" @default.
• W2034367257 hasAuthorship W2034367257A5081242214 @default.
• W2034367257 hasBestOaLocation W20343672571 @default.
• W2034367257 hasConcept C112705442 @default.
• W2034367257 hasConcept C126322002 @default.
• W2034367257 hasConcept C197934379 @default.
• W2034367257 hasConcept C2778375690 @default.
• W2034367257 hasConcept C2780548744 @default.
• W2034367257 hasConcept C2781212610 @default.
• W2034367257 hasConcept C42219234 @default.
• W2034367257 hasConcept C42404028 @default.
• W2034367257 hasConcept C519063684 @default.
• W2034367257 hasConcept C71924100 @default.
• W2034367257 hasConcept C84393581 @default.
• W2034367257 hasConcept C98274493 @default.
• W2034367257 hasConceptScore W2034367257C112705442 @default.
• W2034367257 hasConceptScore W2034367257C126322002 @default.
• W2034367257 hasConceptScore W2034367257C197934379 @default.
• W2034367257 hasConceptScore W2034367257C2778375690 @default.
• W2034367257 hasConceptScore W2034367257C2780548744 @default.
• W2034367257 hasConceptScore W2034367257C2781212610 @default.
• W2034367257 hasConceptScore W2034367257C42219234 @default.
• W2034367257 hasConceptScore W2034367257C42404028 @default.
• W2034367257 hasConceptScore W2034367257C519063684 @default.
• W2034367257 hasConceptScore W2034367257C71924100 @default.
• W2034367257 hasConceptScore W2034367257C84393581 @default.
• W2034367257 hasConceptScore W2034367257C98274493 @default.
• W2034367257 hasIssue "sup1" @default.
• W2034367257 hasLocation W20343672571 @default.
• W2034367257 hasLocation W20343672572 @default.
• W2034367257 hasOpenAccess W2034367257 @default.
• W2034367257 hasPrimaryLocation W20343672571 @default.
• W2034367257 hasRelatedWork W194867891 @default.
• W2034367257 hasRelatedWork W1964803013 @default.
• W2034367257 hasRelatedWork W2015699418 @default.
• W2034367257 hasRelatedWork W2034367257 @default.
• W2034367257 hasRelatedWork W2049790783 @default.
• W2034367257 hasRelatedWork W2076499223 @default.
• W2034367257 hasRelatedWork W2095354666 @default.
• W2034367257 hasRelatedWork W2108009578 @default.
• W2034367257 hasRelatedWork W2413651776 @default.
• W2034367257 hasRelatedWork W3046428350 @default.
• W2034367257 hasVolume "7" @default.
• W2034367257 isParatext "false" @default.
• W2034367257 isRetracted "false" @default.
• W2034367257 magId "2034367257" @default.
• W2034367257 workType "article" @default.