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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034367448> ?p ?o ?g. }

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• W2034367448 abstract "The structural basis for the phosphoryla- tion-dependent regulation of smooth muscle myosin ATPase activity was investigated by forming two- dimensional (2-D) crystalline arrays of expressed unphosphorylated and thiophosphorylated smooth muscle heavy meromyosin (HMM) on positively charged lipid monolayers. A comparison of averaged 2-D projections of both forms at 2.3-nm resolution reveals distinct structural differences. In the active, thiophosphorylated form, the two heads of HMM interact intermolecularly with adjacent molecules. In the unphosphorylated or inhibited state, intramolecular interactions position the actin-binding interface of one head onto the converter domain of the second head, thus providing a mechanism whereby the activity of both heads could be inhibited." @default.
• W2034367448 created "2016-06-24" @default.
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• W2034367448 date "1999-12-27" @default.
• W2034367448 modified "2023-10-18" @default.
• W2034367448 title "Visualization of Head–Head Interactions in the Inhibited State of Smooth Muscle Myosin" @default.
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• W2034367448 doi "https://doi.org/10.1083/jcb.147.7.1385" @default.
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