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• W2034368419 endingPage "271" @default.
• W2034368419 startingPage "255" @default.
• W2034368419 abstract "Exposure to ambient air pollution has been associated with cancer. Ambient air contains a complex mixture of toxics, including particulate matter (PM) and benzene. Carcinogenic effects of PM may relate both to the content of PAH and to oxidative DNA damage generated by transition metals, benzene, metabolism and inflammation. By means of personal monitoring and biomarkers of internal dose, biologically effective dose and susceptibility, it should be possible to characterize individual exposure and identify air pollution sources with relevant biological effects. In a series of studies, individual exposure to PM(2.5), nitrogen dioxide (NO(2)) and benzene has been measured in groups of 40-50 subjects. Measured biomarkers included 1-hydroxypyrene, benzene metabolites (phenylmercapturic acid (PMA) and trans-trans-muconic acid (ttMA)), 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) in urine, DNA strand breaks, base oxidation, 8-oxodG and PAH bulky adducts in lymphocytes, markers of oxidative stress in plasma and genotypes of glutathione transferases (GSTs) and NADPH:quinone reductase (NQO1). With respect to benzene, the main result indicates that DNA base oxidation is correlated with PMA excretion. With respect to exposure to PM, biomarkers of oxidative damage showed significant positive association with the individual exposure. Thus, 8-oxodG in lymphocyte DNA and markers of oxidative damage to lipids and protein in plasma associated with PM(2.5) exposure. Several types of DNA damage showed seasonal variation. PAH adduct levels, DNA strand breaks and 8-oxodG in lymphocytes increased significantly in the summer period, requiring control of confounders. Similar seasonal effects on strand breaks and expression of the relevant DNA repair genes ERCC1 and OGG1 have been reported. In the present setting, biological effects of air pollutants appear mainly related to oxidative stress via personal exposure and not to urban background levels. Future developments include personal time-resolved monitors for exposure to ultrafine PM and PM(2.5,) use of GPS, as well as genomics and proteomics based biomarkers." @default.
• W2034368419 created "2016-06-24" @default.
• W2034368419 creator A5034937943 @default.
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• W2034368419 date "2003-11-01" @default.
• W2034368419 modified "2023-09-28" @default.
• W2034368419 title "Linking exposure to environmental pollutants with biological effects" @default.
• W2034368419 cites W113982714 @default.
• W2034368419 cites W1514869730 @default.
• W2034368419 cites W1525139717 @default.
• W2034368419 cites W1527816314 @default.
• W2034368419 cites W17208169 @default.
• W2034368419 cites W1963712060 @default.
• W2034368419 cites W1964880971 @default.
• W2034368419 cites W1965572779 @default.
• W2034368419 cites W1966104889 @default.
• W2034368419 cites W1967357583 @default.
• W2034368419 cites W1969428572 @default.
• W2034368419 cites W1973081886 @default.
• W2034368419 cites W1974393508 @default.
• W2034368419 cites W1976346227 @default.
• W2034368419 cites W1979010400 @default.
• W2034368419 cites W1979314865 @default.
• W2034368419 cites W1982286202 @default.
• W2034368419 cites W1984643282 @default.
• W2034368419 cites W1986952134 @default.
• W2034368419 cites W1990304962 @default.
• W2034368419 cites W1992214779 @default.
• W2034368419 cites W1994610062 @default.
• W2034368419 cites W1996258759 @default.
• W2034368419 cites W1997753581 @default.
• W2034368419 cites W1999357005 @default.
• W2034368419 cites W2002690139 @default.
• W2034368419 cites W2010202988 @default.
• W2034368419 cites W2011412712 @default.
• W2034368419 cites W2011436989 @default.
• W2034368419 cites W2016662286 @default.
• W2034368419 cites W2018798193 @default.
• W2034368419 cites W2019324716 @default.
• W2034368419 cites W2019337449 @default.
• W2034368419 cites W2020179345 @default.
• W2034368419 cites W2021092719 @default.
• W2034368419 cites W2022307275 @default.
• W2034368419 cites W2023030757 @default.
• W2034368419 cites W2023516284 @default.
• W2034368419 cites W2026260148 @default.
• W2034368419 cites W2030434415 @default.
• W2034368419 cites W2031018453 @default.
• W2034368419 cites W2033958659 @default.
• W2034368419 cites W2035907100 @default.
• W2034368419 cites W2036511966 @default.
• W2034368419 cites W2038210948 @default.
• W2034368419 cites W2038343834 @default.
• W2034368419 cites W2038454366 @default.
• W2034368419 cites W2040071178 @default.
• W2034368419 cites W2040843256 @default.
• W2034368419 cites W2043026265 @default.
• W2034368419 cites W2043426639 @default.
• W2034368419 cites W2045050634 @default.
• W2034368419 cites W2045258300 @default.
• W2034368419 cites W2046336874 @default.
• W2034368419 cites W2046579535 @default.
• W2034368419 cites W2046863348 @default.
• W2034368419 cites W2048308408 @default.
• W2034368419 cites W2052034749 @default.
• W2034368419 cites W2054362610 @default.
• W2034368419 cites W2056017024 @default.
• W2034368419 cites W2059114172 @default.
• W2034368419 cites W2059350976 @default.
• W2034368419 cites W2060514686 @default.
• W2034368419 cites W2062962009 @default.
• W2034368419 cites W2062992995 @default.
• W2034368419 cites W2064501800 @default.
• W2034368419 cites W2065091408 @default.
• W2034368419 cites W2067632605 @default.
• W2034368419 cites W2068336202 @default.
• W2034368419 cites W2069762113 @default.
• W2034368419 cites W2071850731 @default.
• W2034368419 cites W2073200608 @default.
• W2034368419 cites W2073684148 @default.
• W2034368419 cites W2074611106 @default.
• W2034368419 cites W2079628884 @default.
• W2034368419 cites W2081205194 @default.
• W2034368419 cites W2085110243 @default.
• W2034368419 cites W2090687738 @default.
• W2034368419 cites W2092286664 @default.
• W2034368419 cites W2098662035 @default.
• W2034368419 cites W2103449823 @default.
• W2034368419 cites W2105770609 @default.
• W2034368419 cites W2109543726 @default.
• W2034368419 cites W2112710602 @default.
• W2034368419 cites W2113348458 @default.

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