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- W2034370031 abstract "Pancreatic carcinoma etiology and molecular pathogenesis are weakly understood. Based on the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, we studied the association of polymorphisms in the tobacco carcinogen-metabolizing gene CYP2A13 (Arg101Stop) and the alcohol-metabolizing genes ADH1B (Arg48His) and ADH1C (Ile350Val) with pancreatic cancer risk.Polymorphisms were studied by allelic discrimination.In a hospital-based case-control study, CYP2A13 variant alleles coding an inactive enzyme were found in 7 of 265 cancer-free controls and in none of 235 pancreatic carcinoma patients. Neither ADH1B or ADH1C polymorphisms alone nor their combinations showed a significant effect on pancreatic cancer risk.The first study of the roles of CYP2A13, ADH1B, and ADH1C in pancreatic cancer etiology suggested that the controls may have a lower ability to bioactivate tobacco-derived procarcinogens than the cases." @default.
- W2034370031 created "2016-06-24" @default.
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- W2034370031 date "2010-03-01" @default.
- W2034370031 modified "2023-10-05" @default.
- W2034370031 title "CYP2A13, ADH1B, and ADH1C Gene Polymorphisms and Pancreatic Cancer Risk" @default.
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- W2034370031 doi "https://doi.org/10.1097/mpa.0b013e3181bab6c2" @default.
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