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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034370520> ?p ?o ?g. }

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• W2034370520 abstract "Five indole alkaloids, corynantheidine, corynantheine, dihydrocorynantheine, alpha-yohimbine and corynanthine were isolated from bark of Corynanthe pachyceras K. Schum. (Rubiaceae). The structures were established by spectroscopic methods, including previously unreported assignment of all 1H-NMR resonances by COSY and NOESY experiments. These and related alkaloids showed pronounced activity against Leishmania major promastigotes (IC50 at the micromolar level) but no significant in vitro antiplasmodial activity (against chloroquine-sensitive Plasmodium falciparum). Cytotoxicity assessed with drug sensitive KB-3-1 and multidrug-resistant KB-V1 cell lines was low; the alkaloids are apparently not substrates for the P-glycoprotein (P-170) efflux pump." @default.
• W2034370520 created "2016-06-24" @default.
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• W2034370520 date "2000-08-01" @default.
• W2034370520 modified "2023-10-12" @default.
• W2034370520 title "Leishmanicidal, Antiplasmodial and Cytotoxic Activity of Indole Alkaloids from Corynanthe pachyceras" @default.
• W2034370520 doi "https://doi.org/10.1055/s-2000-8661" @default.
• W2034370520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10985079" @default.
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