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- W2034371347 abstract "In this study, a cell-penetrating peptide, the transactivating transcriptional factor (TAT) domain from HIV, was linked to a chitosan/doxorubicin (chitosan/DOX) conjugate to form a chitosan/DOX/TAT hybrid. The synthesized chitosan/DOX/TAT conjugate showed a different intracellular distribution pattern from a conjugate without TAT. Unlike both free DOX and the conjugate without TAT, the chitosan/DOX/TAT conjugate was capable of efficient cell entry. The chitosan/DOX/TAT conjugate was found to be highly cytotoxic, with an IC(50) value of approximately 480 nM, 2 times less than that of chitosan/DOX (980 nM). The chitosan/DOX/TAT provided decreases in tumor volume of 77.4 and 57.5% compared to free DOX and chitosan/DOX, respectively, in tumor-bearing mice. Therefore, this study suggests that TAT-mediated chitosan/DOX conjugate delivery is effective in slowing tumor growth." @default.
- W2034371347 created "2016-06-24" @default.
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- W2034371347 date "2010-07-28" @default.
- W2034371347 modified "2023-10-13" @default.
- W2034371347 title "Cell‐penetrating chitosan/doxorubicin/TAT conjugates for efficient cancer therapy" @default.
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- W2034371347 doi "https://doi.org/10.1002/ijc.25578" @default.
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