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- W2034372638 abstract "Extraosseous tumours of the skin were observed in three patients with multiple myeloma. Routine histopathologic study of paraffin-embedded specimens from these tumors suggested the diagnosis of lymphoma or reticulum-cell sarcoma. The cutaneous myeloma cells stained in a characteristic fashion with methyl green-pyronin and touch imprints of the tumors stained with Wright's stain demonstrated, however, typical myeloma cells. The myeloma serum proteins from two patients were characterized as IgG-L and BJP-K, respectively. These immunoglobulins or immunoglobulin fragments were not demonstrated in the cutaneous metastases by direct fluorescent staining. Touch imprints from one tumor revealed positive cytoplasmic staining for IgM-K and IgM-L in medium-sized lymphocytes, but not in tumor cells. In cryostat-sectioned specimens from this tumor, these fluorescent cells appeared to buttress the tumor masses in the skin. The possibility that these cells may reflect a host mechanism for rejecting tumor cells is suggested." @default.
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- W2034372638 date "1969-08-01" @default.
- W2034372638 modified "2023-09-25" @default.
- W2034372638 title "Cutaneous Extramedullary Plasmacytomas" @default.
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- W2034372638 doi "https://doi.org/10.1001/archderm.1969.01610260031005" @default.
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