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- W2034372713 abstract "The starting material O-protected glycosyl isothiocyanate (1˜3) was refluxed with 1,4-diaminobenzene in CHCl3 under nitrogen atmosphere to give 1,4-bis(N-glycosyl)thioureidobenzene (4˜6). Then 1,4-bis[N-(4/6-substituted benzothiazole-2-yl)-N′-glycosylguanidino]benzenes (8a˜8e, 9a˜9e, 10a˜10e) were obtained in good yield by reaction of compounds (4˜6) with 2-amino-4/6-benzothizoles (7a˜7e) and HgCl2 in the presence of TEA in DMF. The structures of all 18 new compounds were confirmed by IR, 1H NMR, LC-MS and elemental analysis. The bioactivity of anti-HIV-1 protease (HIV-1 PR) and against angiotensin converting enzyme (ACE) have been evaluated." @default.
- W2034372713 created "2016-06-24" @default.
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- W2034372713 date "2007-10-01" @default.
- W2034372713 modified "2023-10-16" @default.
- W2034372713 title "The Synthesis of 1,4-Bis[<i>N</i>-(4/6-Substituted Benzothiazole-2-yl)-<i>N</i>′-Glycosylguanidino]Benzenes" @default.
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- W2034372713 doi "https://doi.org/10.1002/jccs.200700195" @default.
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