FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034372962> ?p ?o ?g. }

• W2034372962 endingPage "704" @default.
• W2034372962 startingPage "697" @default.
• W2034372962 abstract "Beta-blockade results in rapid glucose clearance and premature fatigue during exercise. To investigate the cause of this increased glucose clearance, we studied the acute effects of propranolol on insulin-stimulated muscle glucose uptake during contraction in the presence of epinephrine with an isolated rat muscle preparation. Glucose uptake increased in both fast- (epitrochlearis) and slow-twitch (soleus) muscle during insulin or contraction stimulation. In the presence of 24 nM epinephrine, glucose uptake during contraction was completely suppressed when insulin was present. This suppression of glucose uptake by epinephrine was accompanied by a decrease in insulin receptor substrate (IRS)-1-phosphatidylinositol 3 (PI3)-kinase activity. Propranolol had no direct effect on insulin-stimulated glucose uptake during contraction. However, epinephrine was ineffective in attenuating insulin-stimulated glucose uptake during contraction in the presence of propranolol. This ineffectiveness of epinephrine to suppress insulin-stimulated glucose uptake during contraction occurred in conjunction with its inability to completely suppress IRS-1-PI3-kinase activity. Results of this study indicate that the effectiveness of epinephrine to inhibit insulin-stimulated glucose uptake during contraction is severely diminished in muscle exposed to propranolol. Thus the increase in glucose clearance and premature fatigue associated with beta-blockade could result from the inability of epinephrine to attenuate insulin-stimulated muscle glucose uptake." @default.
• W2034372962 created "2016-06-24" @default.
• W2034372962 creator A5001347059 @default.
• W2034372962 creator A5053177785 @default.
• W2034372962 creator A5057993569 @default.
• W2034372962 date "2002-08-01" @default.
• W2034372962 modified "2023-10-06" @default.
• W2034372962 title "Propranolol prevents epinephrine from limiting insulin-stimulated muscle glucose uptake during contraction" @default.
• W2034372962 cites W1483819615 @default.
• W2034372962 cites W1774190872 @default.
• W2034372962 cites W1782753704 @default.
• W2034372962 cites W181107845 @default.
• W2034372962 cites W1830365929 @default.
• W2034372962 cites W1875958179 @default.
• W2034372962 cites W191749779 @default.
• W2034372962 cites W1932762496 @default.
• W2034372962 cites W1943565665 @default.
• W2034372962 cites W1966063655 @default.
• W2034372962 cites W2006783700 @default.
• W2034372962 cites W2008924437 @default.
• W2034372962 cites W2013715490 @default.
• W2034372962 cites W2024092840 @default.
• W2034372962 cites W2036610814 @default.
• W2034372962 cites W2039437281 @default.
• W2034372962 cites W2039466175 @default.
• W2034372962 cites W2065225601 @default.
• W2034372962 cites W2075960772 @default.
• W2034372962 cites W2097256298 @default.
• W2034372962 cites W2098701756 @default.
• W2034372962 cites W2102459549 @default.
• W2034372962 cites W2103557599 @default.
• W2034372962 cites W2104320924 @default.
• W2034372962 cites W2105806276 @default.
• W2034372962 cites W2122488312 @default.
• W2034372962 cites W2122925464 @default.
• W2034372962 cites W2124948826 @default.
• W2034372962 cites W2127965541 @default.
• W2034372962 cites W2140143072 @default.
• W2034372962 cites W2151763612 @default.
• W2034372962 cites W2174936197 @default.
• W2034372962 cites W2177038519 @default.
• W2034372962 cites W2188045383 @default.
• W2034372962 cites W2189412469 @default.
• W2034372962 cites W2237508147 @default.
• W2034372962 cites W2269253612 @default.
• W2034372962 cites W2274721193 @default.
• W2034372962 cites W2338118996 @default.
• W2034372962 cites W2340338748 @default.
• W2034372962 cites W2395978034 @default.
• W2034372962 doi "https://doi.org/10.1152/japplphysiol.00017.2002" @default.
• W2034372962 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12133881" @default.
• W2034372962 hasPublicationYear "2002" @default.
• W2034372962 type Work @default.
• W2034372962 sameAs 2034372962 @default.
• W2034372962 citedByCount "9" @default.
• W2034372962 countsByYear W20343729622013 @default.
• W2034372962 countsByYear W20343729622014 @default.
• W2034372962 countsByYear W20343729622017 @default.
• W2034372962 crossrefType "journal-article" @default.
• W2034372962 hasAuthorship W2034372962A5001347059 @default.
• W2034372962 hasAuthorship W2034372962A5053177785 @default.
• W2034372962 hasAuthorship W2034372962A5057993569 @default.
• W2034372962 hasConcept C126322002 @default.
• W2034372962 hasConcept C134018914 @default.
• W2034372962 hasConcept C161573976 @default.
• W2034372962 hasConcept C163415756 @default.
• W2034372962 hasConcept C17093226 @default.
• W2034372962 hasConcept C185592680 @default.
• W2034372962 hasConcept C2775859304 @default.
• W2034372962 hasConcept C2776050358 @default.
• W2034372962 hasConcept C2777866211 @default.
• W2034372962 hasConcept C2778151854 @default.
• W2034372962 hasConcept C2779306644 @default.
• W2034372962 hasConcept C71924100 @default.
• W2034372962 hasConceptScore W2034372962C126322002 @default.
• W2034372962 hasConceptScore W2034372962C134018914 @default.
• W2034372962 hasConceptScore W2034372962C161573976 @default.
• W2034372962 hasConceptScore W2034372962C163415756 @default.
• W2034372962 hasConceptScore W2034372962C17093226 @default.
• W2034372962 hasConceptScore W2034372962C185592680 @default.
• W2034372962 hasConceptScore W2034372962C2775859304 @default.
• W2034372962 hasConceptScore W2034372962C2776050358 @default.
• W2034372962 hasConceptScore W2034372962C2777866211 @default.
• W2034372962 hasConceptScore W2034372962C2778151854 @default.
• W2034372962 hasConceptScore W2034372962C2779306644 @default.
• W2034372962 hasConceptScore W2034372962C71924100 @default.
• W2034372962 hasIssue "2" @default.
• W2034372962 hasLocation W20343729621 @default.
• W2034372962 hasLocation W20343729622 @default.
• W2034372962 hasOpenAccess W2034372962 @default.
• W2034372962 hasPrimaryLocation W20343729621 @default.
• W2034372962 hasRelatedWork W1971859682 @default.
• W2034372962 hasRelatedWork W1994965139 @default.
• W2034372962 hasRelatedWork W2107510101 @default.
• W2034372962 hasRelatedWork W2414633774 @default.
• W2034372962 hasRelatedWork W2547069902 @default.
• W2034372962 hasRelatedWork W2726421366 @default.
• W2034372962 hasRelatedWork W2745827302 @default.

• next