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• W2034373036 startingPage "F412" @default.
• W2034373036 abstract "Adenosine can mediate the tubuloglomerular (TGF) response via activation of A 1 receptors on the afferent arteriole, but both adenosine A 1 and A 2 receptors can regulate preglomerular resistance. We tested the hypothesis that adenosine A 2 receptors offset the effect of A 1 receptors and modulate the TGF. Maximal TGF responses were measured in male Sprague-Dawley rats as changes in proximal stop-flow pressure (ΔP SF ) in response to increased perfusion of the loop of Henle (0 to 40 nl/min) with artificial tubular fluid (ATF). The maximal TGF response was studied after 5 min of intratubular perfusion (10 nl/min) with ATF alone, or with ATF plus the A 2A receptor antagonist (ZM-241385; 10 −7 or 10 −5 mol/l), A 1 receptor antagonist (PSB-36; 10 −8 mol/l), or with a combination of A 1 (PSB-36; 10 −8 mol/l) and A 2A (ZM-241385; 10 −7 mol/l) antagonists. The maximal TGF response (ΔP SF ) with ATF alone was 11.7 ± 1.0 mmHg. Specific A 2 inhibition (low dose) enhanced the maximal TGF response (15.7 ± 0.8 mmHg; P < 0.01), whereas a high dose (unspecific inhibition) attenuated the response (5.0 ± 0.4 mmHg; P < 0.001). A 1 inhibition alone led to a paradoxical TGF response, with an increase in P SF of 3.1 ± 0.5 mmHg ( P < 0.05). Simultaneous application of A 1 and A 2 antagonists abolished the TGF response (ΔP SF : 0.4 ± 0.3 mmHg). In conclusion, adenosine A 2 receptors modulate the TGF response by counteracting the effects of adenosine A 1 receptors." @default.
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• W2034373036 date "2010-08-01" @default.
• W2034373036 modified "2023-10-17" @default.
• W2034373036 title "Adenosine A₂ receptors modulate tubuloglomerular feedback" @default.
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• W2034373036 doi "https://doi.org/10.1152/ajprenal.00211.2010" @default.
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