Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034373462> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2034373462 endingPage "185" @default.
- W2034373462 startingPage "179" @default.
- W2034373462 abstract "Fourteen patients with allergic asthma and exercise-induced bronchoconstriction (EIB) completed this study. Effects of a 6-week treatment with inhaled budesonide, daily dose 4×0.1 mg, were compared to the effects of treatment with placebo on patient symptom score, clinical assessment score, additional β2-agonist use, lung function indices, PC20 histamine and degree of EIB. Furthermore, relationships between these parameters during treatment with placebo and budesonide were analysed. Treatment with budesonide significantly improved symptom scores, FEV1 and morning peak expiratory flow rate (PEFR). A clear decrease in additional β2-agonist use was observed. PC20 histamine increased significantly, whereas EIB decreased significantly. Patient symptom scores and clinical assessment scores showed a significant correlation before and after treatment. No relationship was observed between these scores and other parameters, except for nocturnal dyspnoea/wheeze correlating significantly with β2-agonist use before treatment with budesonide. There was a significant correlation between β2-agonist use before treatment with budesonide and FEV1, morning PEFR, diurnal variation in PEFR, PC20 histamine and EIB. During treatment with budesonide only a significant correlation of β2-agonist use with PC20 histamine remained. FEV1 before treatment correlated with PEFR, diurnal variation in PEFR and EIB significantly. During treatment with budesonide the relationship of FEV1 with EIB was no longer observed. Diurnal variation in PEFR correlated with EIB significantly only before treatment. It is concluded that symptom scores are of little value in contrast to the measurement of β2-agonist use, lung function indices and airway hyperresponsiveness in the assessment of asthma patients. In spite of treatment with corticosteroids a need for additional β2-agonist use remains, correlating significantly with PC20 histamine. In our view this indicates the importance of assessing PC20 histamine as a measurement of hyperresponsiveness and continuing disease, but also as a guide for pharmacological treatment. However, measurement of EIB appeared to be more sensitive to study the effects of treatment on airway hyperresponsiveness." @default.
- W2034373462 created "2016-06-24" @default.
- W2034373462 creator A5021049929 @default.
- W2034373462 creator A5022838914 @default.
- W2034373462 creator A5050194224 @default.
- W2034373462 date "1989-01-01" @default.
- W2034373462 modified "2023-09-25" @default.
- W2034373462 title "Effects of inhaled budesonide on the relationships between symptoms, lung function indices and airway hyperresponsiveness in patients with allergic asthma" @default.
- W2034373462 cites W1672263440 @default.
- W2034373462 cites W1705185877 @default.
- W2034373462 cites W192372067 @default.
- W2034373462 cites W1959408455 @default.
- W2034373462 cites W1971759873 @default.
- W2034373462 cites W1975790353 @default.
- W2034373462 cites W1979025004 @default.
- W2034373462 cites W2012674650 @default.
- W2034373462 cites W2018030971 @default.
- W2034373462 cites W2025452840 @default.
- W2034373462 cites W2027831840 @default.
- W2034373462 cites W2031867711 @default.
- W2034373462 cites W2033504662 @default.
- W2034373462 cites W2042037258 @default.
- W2034373462 cites W2049239278 @default.
- W2034373462 cites W2056474311 @default.
- W2034373462 cites W2071754888 @default.
- W2034373462 cites W2076796337 @default.
- W2034373462 cites W2093606507 @default.
- W2034373462 cites W2105883431 @default.
- W2034373462 cites W2137401824 @default.
- W2034373462 cites W2287495207 @default.
- W2034373462 cites W2399236744 @default.
- W2034373462 cites W2412583831 @default.
- W2034373462 doi "https://doi.org/10.1016/s0952-0600(89)80015-8" @default.
- W2034373462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2520343" @default.
- W2034373462 hasPublicationYear "1989" @default.
- W2034373462 type Work @default.
- W2034373462 sameAs 2034373462 @default.
- W2034373462 citedByCount "4" @default.
- W2034373462 crossrefType "journal-article" @default.
- W2034373462 hasAuthorship W2034373462A5021049929 @default.
- W2034373462 hasAuthorship W2034373462A5022838914 @default.
- W2034373462 hasAuthorship W2034373462A5050194224 @default.
- W2034373462 hasConcept C1122143 @default.
- W2034373462 hasConcept C126322002 @default.
- W2034373462 hasConcept C142724271 @default.
- W2034373462 hasConcept C170493617 @default.
- W2034373462 hasConcept C19720800 @default.
- W2034373462 hasConcept C204787440 @default.
- W2034373462 hasConcept C27081682 @default.
- W2034373462 hasConcept C2776042228 @default.
- W2034373462 hasConcept C2776136866 @default.
- W2034373462 hasConcept C2776178081 @default.
- W2034373462 hasConcept C2776238763 @default.
- W2034373462 hasConcept C2776804153 @default.
- W2034373462 hasConcept C2777714996 @default.
- W2034373462 hasConcept C2778338976 @default.
- W2034373462 hasConcept C2778938600 @default.
- W2034373462 hasConcept C42219234 @default.
- W2034373462 hasConcept C71924100 @default.
- W2034373462 hasConceptScore W2034373462C1122143 @default.
- W2034373462 hasConceptScore W2034373462C126322002 @default.
- W2034373462 hasConceptScore W2034373462C142724271 @default.
- W2034373462 hasConceptScore W2034373462C170493617 @default.
- W2034373462 hasConceptScore W2034373462C19720800 @default.
- W2034373462 hasConceptScore W2034373462C204787440 @default.
- W2034373462 hasConceptScore W2034373462C27081682 @default.
- W2034373462 hasConceptScore W2034373462C2776042228 @default.
- W2034373462 hasConceptScore W2034373462C2776136866 @default.
- W2034373462 hasConceptScore W2034373462C2776178081 @default.
- W2034373462 hasConceptScore W2034373462C2776238763 @default.
- W2034373462 hasConceptScore W2034373462C2776804153 @default.
- W2034373462 hasConceptScore W2034373462C2777714996 @default.
- W2034373462 hasConceptScore W2034373462C2778338976 @default.
- W2034373462 hasConceptScore W2034373462C2778938600 @default.
- W2034373462 hasConceptScore W2034373462C42219234 @default.
- W2034373462 hasConceptScore W2034373462C71924100 @default.
- W2034373462 hasIssue "4" @default.
- W2034373462 hasLocation W20343734621 @default.
- W2034373462 hasLocation W20343734622 @default.
- W2034373462 hasOpenAccess W2034373462 @default.
- W2034373462 hasPrimaryLocation W20343734621 @default.
- W2034373462 hasRelatedWork W1983034461 @default.
- W2034373462 hasRelatedWork W2018965898 @default.
- W2034373462 hasRelatedWork W2042971169 @default.
- W2034373462 hasRelatedWork W2060279005 @default.
- W2034373462 hasRelatedWork W2063656508 @default.
- W2034373462 hasRelatedWork W2114437823 @default.
- W2034373462 hasRelatedWork W2295504875 @default.
- W2034373462 hasRelatedWork W2409805981 @default.
- W2034373462 hasRelatedWork W2805897484 @default.
- W2034373462 hasRelatedWork W3026608136 @default.
- W2034373462 hasVolume "1" @default.
- W2034373462 isParatext "false" @default.
- W2034373462 isRetracted "false" @default.
- W2034373462 magId "2034373462" @default.
- W2034373462 workType "article" @default.