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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034374524> ?p ?o ?g. }

• W2034374524 endingPage "416" @default.
• W2034374524 startingPage "413" @default.
• W2034374524 abstract "The basal lamina that ensheaths skeletal muscle fibers traverses the synaptic cleft at the neuromuscular junction. Synaptic and extrasynaptic portions of the basal lamina contain different laminin beta chains: beta 2 (or s) at synapses and beta 1 (or B1) extrasynaptically. Laminin beta 2 is also confined to synapselike patches on myotube surfaces in vitro, whereas beta 1 is present throughout the extracellular matrix. This differential localization of laminin beta chains was analyzed by expression of chimeric beta 1-beta 2 molecules in cultured mouse myotubes. A 16-amino acid carboxyl-terminal sequence in beta 2 was necessary for synaptic localization, and an amino-terminal domain in beta 1 promoted association with extracellular fibrils. The synaptic targeting sequence of beta 2 contains a site previously shown to be adhesive for motor neurons." @default.
• W2034374524 created "2016-06-24" @default.
• W2034374524 creator A5067215838 @default.
• W2034374524 creator A5083328627 @default.
• W2034374524 creator A5091813085 @default.
• W2034374524 date "1995-07-21" @default.
• W2034374524 modified "2023-10-17" @default.
• W2034374524 title "A Synaptic Localization Domain in the Synaptic Cleft Protein Laminin β2 (s-Laminin)" @default.
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• W2034374524 doi "https://doi.org/10.1126/science.7618109" @default.
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