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• W2034374987 endingPage "C1362" @default.
• W2034374987 startingPage "C1353" @default.
• W2034374987 abstract "We report a novel form of modulation of T-type calcium currents carried out by the neuronal actin-binding protein (ABP) Kelch-like 1 (KLHL1). KLHL1 is a constitutive neuronal ABP localized to the soma and dendritic arbors; its genetic elimination in Purkinje neurons leads to dendritic atrophy and motor insufficiency. KLHL1 participates in neurite outgrowth and upregulates voltage-gated P/Q-type calcium channel function; here we investigated KLHL1's role as a modulator of low-voltage-gated calcium channels and determined the molecular mechanism of this modulation with electrophysiology and biochemistry. Coexpression of KLHL1 with Ca V 3.1 or Ca V 3.2 (α 1G or α 1H subunits) caused increases in T-type current density (35%) and calcium influx (75–83%) when carried out by α 1H but not by α 1G . The association between KLHL1 and α 1H was determined by immunoprecipitation and immunolocalization in brain membrane fractions and in vitro in HEK-293 cells. Noise analysis showed that neither α 1H single-channel conductance nor open probability was altered by KLHL1, yet a significant increase in channel number was detected and further corroborated by Western blot analysis. KLHL1 also induced an increase in α 1H current deactivation time (τ deactivation ). Interestingly, the majority of KLHL1's effects were eliminated when the actin-binding motif (kelch) was removed, with the exception of the calcium influx increase during action potentials, indicating that KLHL1 interacts with α 1H and actin and selectively regulates α 1H function by increasing the number of α 1H channels. This constitutes a novel regulatory mechanism of T-type calcium currents and supports the role of KLHL1 in the modulation of cellular excitability." @default.
• W2034374987 created "2016-06-24" @default.
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• W2034374987 date "2010-06-01" @default.
• W2034374987 modified "2023-10-18" @default.
• W2034374987 title "T-type current modulation by the actin-binding protein Kelch-like 1" @default.
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• W2034374987 doi "https://doi.org/10.1152/ajpcell.00235.2009" @default.
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