FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034376715> ?p ?o ?g. }

• W2034376715 abstract "Surgical pain is managed with multi-modal anaesthesia in total hip replacement (THR) and total knee replacement (TKR). It is unclear whether including local anaesthetic infiltration before wound closure provides additional pain control. We performed a systematic review of randomised controlled trials of local anaesthetic infiltration in patients receiving THR or TKR. We searched MEDLINE, Embase and Cochrane CENTRAL to December 2012. Two reviewers screened abstracts, extracted data, and contacted authors for unpublished outcomes and data. Outcomes collected were post-operative pain at rest and during activity after 24 and 48 hours, opioid requirement, mobilisation, hospital stay and complications. When feasible, we estimated pooled treatment effects using random effects meta-analyses. In 13 studies including 909 patients undergoing THR, patients receiving local anaesthetic infiltration experienced a greater reduction in pain at 24 hours at rest by standardised mean difference (SMD) -0.61 (95% CI -1.05, -0.16; p = 0.008) and by SMD -0.43 (95% CI -0.78 -0.09; p = 0.014) at 48 hours during activity. In TKR, diverse multi-modal regimens were reported. In 23 studies including 1439 patients undergoing TKR, local anaesthetic infiltration reduced pain on average by SMD -0.40 (95% CI -0.58, -0.22; p < 0.001) at 24 hours at rest and by SMD -0.27 (95% CI -0.50, -0.05; p = 0.018) at 48 hours during activity, compared with patients receiving no infiltration or placebo. There was evidence of a larger reduction in studies delivering additional local anaesthetic after wound closure. There was no evidence of pain control additional to that provided by femoral nerve block. Patients receiving local anaesthetic infiltration spent on average an estimated 0.83 (95% CI 1.54, 0.12; p = 0.022) and 0.87 (95% CI 1.62, 0.11; p = 0.025) fewer days in hospital after THR and TKR respectively, had reduced opioid consumption, earlier mobilisation, and lower incidence of vomiting. Few studies reported long-term outcomes. Local anaesthetic infiltration is effective in reducing short-term pain and hospital stay in patients receiving THR and TKR. Studies should assess whether local anaesthetic infiltration can prevent long-term pain. Enhanced pain control with additional analgesia through a catheter should be weighed against a possible infection risk." @default.
• W2034376715 created "2016-06-24" @default.
• W2034376715 creator A5002491485 @default.
• W2034376715 creator A5017697853 @default.
• W2034376715 creator A5056759579 @default.
• W2034376715 creator A5071306973 @default.
• W2034376715 creator A5083372234 @default.
• W2034376715 creator A5009664826 @default.
• W2034376715 date "2014-07-05" @default.
• W2034376715 modified "2023-10-06" @default.
• W2034376715 title "Local anaesthetic infiltration for peri-operative pain control in total hip and knee replacement: systematic review and meta-analyses of short- and long-term effectiveness" @default.
• W2034376715 cites W1598602811 @default.
• W2034376715 cites W1910171443 @default.
• W2034376715 cites W1914039760 @default.
• W2034376715 cites W1917593090 @default.
• W2034376715 cites W1957937187 @default.
• W2034376715 cites W1966182511 @default.
• W2034376715 cites W1969278940 @default.
• W2034376715 cites W1985190510 @default.
• W2034376715 cites W1985258817 @default.
• W2034376715 cites W1990076794 @default.
• W2034376715 cites W1992205326 @default.
• W2034376715 cites W1995600798 @default.
• W2034376715 cites W1998417724 @default.
• W2034376715 cites W2000740569 @default.
• W2034376715 cites W2004000781 @default.
• W2034376715 cites W2009024168 @default.
• W2034376715 cites W2010747700 @default.
• W2034376715 cites W2011649789 @default.
• W2034376715 cites W2016461191 @default.
• W2034376715 cites W2017090834 @default.
• W2034376715 cites W2018494938 @default.
• W2034376715 cites W2020805037 @default.
• W2034376715 cites W2026572108 @default.
• W2034376715 cites W2029468390 @default.
• W2034376715 cites W2030646884 @default.
• W2034376715 cites W2032459598 @default.
• W2034376715 cites W2036200344 @default.
• W2034376715 cites W204046373 @default.
• W2034376715 cites W2044821056 @default.
• W2034376715 cites W2045766622 @default.
• W2034376715 cites W2046078971 @default.
• W2034376715 cites W2052145417 @default.
• W2034376715 cites W2054747465 @default.
• W2034376715 cites W2055461942 @default.
• W2034376715 cites W2070140892 @default.
• W2034376715 cites W2076674913 @default.
• W2034376715 cites W2078873074 @default.
• W2034376715 cites W2079188040 @default.
• W2034376715 cites W2082874550 @default.
• W2034376715 cites W2089501150 @default.
• W2034376715 cites W2093536899 @default.
• W2034376715 cites W2094686591 @default.
• W2034376715 cites W2096889558 @default.
• W2034376715 cites W2098906492 @default.
• W2034376715 cites W2108834764 @default.
• W2034376715 cites W2109792197 @default.
• W2034376715 cites W2111404291 @default.
• W2034376715 cites W2116330131 @default.
• W2034376715 cites W2119605658 @default.
• W2034376715 cites W2122099789 @default.
• W2034376715 cites W2125138999 @default.
• W2034376715 cites W2126930838 @default.
• W2034376715 cites W2128076015 @default.
• W2034376715 cites W2136107492 @default.
• W2034376715 cites W2137085579 @default.
• W2034376715 cites W2139394319 @default.
• W2034376715 cites W2139711196 @default.
• W2034376715 cites W2142531663 @default.
• W2034376715 cites W2146905193 @default.
• W2034376715 cites W2153337371 @default.
• W2034376715 cites W2154209969 @default.
• W2034376715 cites W2161073616 @default.
• W2034376715 cites W2161668911 @default.
• W2034376715 cites W2171163304 @default.
• W2034376715 cites W2261453920 @default.
• W2034376715 cites W2320350515 @default.
• W2034376715 cites W2398385484 @default.
• W2034376715 cites W2468996569 @default.
• W2034376715 cites W98600822 @default.
• W2034376715 doi "https://doi.org/10.1186/1471-2474-15-220" @default.
• W2034376715 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4118275" @default.
• W2034376715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24996539" @default.
• W2034376715 hasPublicationYear "2014" @default.
• W2034376715 type Work @default.
• W2034376715 sameAs 2034376715 @default.
• W2034376715 citedByCount "94" @default.
• W2034376715 countsByYear W20343767152014 @default.
• W2034376715 countsByYear W20343767152015 @default.
• W2034376715 countsByYear W20343767152016 @default.
• W2034376715 countsByYear W20343767152017 @default.
• W2034376715 countsByYear W20343767152018 @default.
• W2034376715 countsByYear W20343767152019 @default.
• W2034376715 countsByYear W20343767152020 @default.
• W2034376715 countsByYear W20343767152021 @default.
• W2034376715 countsByYear W20343767152022 @default.
• W2034376715 countsByYear W20343767152023 @default.
• W2034376715 crossrefType "journal-article" @default.
• W2034376715 hasAuthorship W2034376715A5002491485 @default.
• W2034376715 hasAuthorship W2034376715A5009664826 @default.

• next