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• W2034378114 abstract "Insulin, a small hormone protein comprising 51 residues in two disulfide-linked polypeptide chains, adopts a predominantly α-helical conformation in its native state. It readily undergoes protein misfolding and aggregates into amyloid fibrils under a variety of conditions. Insulin is a unique model system in which to study protein fibrillization, since its three disulfide bridges are retained in the fibrillar state and thus limit the conformational space available to the polypeptide chains during misfolding and fibrillization. Taking into account this unique conformational restriction, we modeled possible monomeric subunits of the insulin amyloid fibrils using β-solenoid folds, namely, the β-helix and β-roll. Both models agreed with currently available biophysical data. We performed molecular dynamics simulations, which allowed some limited insights into the relative structural stability, suggesting that the β-roll subunit model may be more stable than the β-helix subunit model. We also constructed β-solenoid-based insulin fibril models and conducted fiber diffraction simulation to identify plausible fibril architectures of insulin amyloid. A comparison of simulated fiber diffraction patterns of the fibril models to the experimental insulin x-ray fiber diffraction data suggests that the model fibers composed of six twisted β-roll protofilaments provide the most reasonable fit to available experimental diffraction patterns and previous biophysical studies." @default.
• W2034378114 created "2016-06-24" @default.
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• W2034378114 date "2009-12-01" @default.
• W2034378114 modified "2023-10-18" @default.
• W2034378114 title "Molecular Modeling of the Misfolded Insulin Subunit and Amyloid Fibril" @default.
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• W2034378114 doi "https://doi.org/10.1016/j.bpj.2009.09.042" @default.
• W2034378114 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2793351" @default.
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