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• W2034378573 abstract "This work describes the preparation, the physicochemical properties and the stability of pentamidine-loaded poly(d,l-lactide) nanoparticles. The nanoprecipitation method was used and various concentrations of phospholipids and poloxamer tested. The pentamidine concentration was 0.5 mg/ml. The percentage of pentamidine binding varied and was dependent on the phospholipid concentration. The highest binding percentage (75.8%±1.8) was obtained with the highest concentration of phospholipids (1.25% w/v). All formulations tested presented monodispersed nanoparticles with a mean diameter of between 131 and 154 nm. The pH of tested formulations ranged from 7.5 to 8. After 9 months of storage at 4°C, all formulations were stable. Nevertheless, a pentamidine release of between 12 and 21% was observed. Exponential dependence of the amount of drug release on time was evidenced (r>0.98). The stability studies have also shown a significant decrease of pH (2 units), a nanoparticle size not significantly modified and an unchanged morphology." @default.
• W2034378573 created "2016-06-24" @default.
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• W2034378573 date "1997-12-01" @default.
• W2034378573 modified "2023-10-01" @default.
• W2034378573 title "Pentamidine-loaded poly(d,l-lactide) nanoparticles: physicochemical properties and stability work" @default.
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• W2034378573 doi "https://doi.org/10.1016/s0378-5173(97)00291-3" @default.
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