FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034379220> ?p ?o ?g. }

• W2034379220 endingPage "1981" @default.
• W2034379220 startingPage "1974" @default.
• W2034379220 abstract "The aim of the study was to analyze the behavior of oxidative stress and its interplay with CD40L, a protein that is implicated in atherosclerosis, in hypercholesterolemic children. Oxidative stress has been suggested to play a major role in premature atherosclerosis. Forty-one children with hypercholesterolemia (mean age 9.28 ± 0.5 years) and 40 children with normocholesterolemia (mean age 9.02 ± 0.69 years) were matched for gender and age. Within each group, children were classified as having or not having a family history of cardiovascular disease. Serum levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of oxidative stress, and plasma levels of soluble CD40L (sCD40L) were measured in each child. In a subgroup of children with high (n = 8) or normal (n = 8) levels of serum cholesterol, platelet p38 mitogen-activated protein (MAP) kinase phosphorylation, a protein involved in the activation of nicotinamide adenine dinucleotide phosphate oxidase, was determined. Children with hypercholesterolemia had higher values of 8-OHdG and sCD40L compared with control subjects (0.55 ± 0.06 ng/ml vs. 0.21 ± 0.02 ng/ml, p < 0.001 and 0.55 ± 0.04 ng/ml vs. 0.19 ± 0.03 ng/ml, p < 0.001, respectively). A significant correlation between 8-OHdG and sCD40L was observed in children with high (r = 0.676, p < 0.001) or normal (r = 0.878, p < 0.001) levels of cholesterol. Children with a family history of cardiovascular disease tended to have higher values of 8-OHdG and sCD40L, but the difference was not significant. Analysis of platelet p38 MAP kinase showed that it was phosphorylated more in children with hypercholesterolemia compared with control subjects (36.8 ± 5.8 AU vs. 8.0 ± 4.5 AU, p < 0.001 respectively). Children with hypercholesterolemia have an early increase of oxidative stress that may be responsible for up-regulation of CD40L and potentially predispose to premature atherosclerosis." @default.
• W2034379220 created "2016-06-24" @default.
• W2034379220 creator A5006406707 @default.
• W2034379220 creator A5022431115 @default.
• W2034379220 creator A5043544659 @default.
• W2034379220 creator A5071427601 @default.
• W2034379220 creator A5073298026 @default.
• W2034379220 creator A5078570290 @default.
• W2034379220 creator A5080359948 @default.
• W2034379220 creator A5081652370 @default.
• W2034379220 date "2007-05-01" @default.
• W2034379220 modified "2023-10-17" @default.
• W2034379220 title "Early Increase of Oxidative Stress and Soluble CD40L in Children With Hypercholesterolemia" @default.
• W2034379220 cites W1977285875 @default.
• W2034379220 cites W1981243382 @default.
• W2034379220 cites W1989045605 @default.
• W2034379220 cites W2008842767 @default.
• W2034379220 cites W2020951193 @default.
• W2034379220 cites W2025733426 @default.
• W2034379220 cites W2030578737 @default.
• W2034379220 cites W2031276193 @default.
• W2034379220 cites W2032786707 @default.
• W2034379220 cites W2042154143 @default.
• W2034379220 cites W2053277534 @default.
• W2034379220 cites W2054540030 @default.
• W2034379220 cites W2064729923 @default.
• W2034379220 cites W2077028130 @default.
• W2034379220 cites W2084383114 @default.
• W2034379220 cites W2091050865 @default.
• W2034379220 cites W2100746120 @default.
• W2034379220 cites W2107415987 @default.
• W2034379220 cites W2118621126 @default.
• W2034379220 cites W2119242783 @default.
• W2034379220 cites W2129380027 @default.
• W2034379220 cites W2133591735 @default.
• W2034379220 cites W2145655051 @default.
• W2034379220 cites W2146601825 @default.
• W2034379220 cites W2148549077 @default.
• W2034379220 cites W2152223019 @default.
• W2034379220 cites W2155932961 @default.
• W2034379220 cites W2160274249 @default.
• W2034379220 cites W2162934638 @default.
• W2034379220 cites W2163793010 @default.
• W2034379220 cites W2167772905 @default.
• W2034379220 cites W2336250349 @default.
• W2034379220 cites W31408407 @default.
• W2034379220 doi "https://doi.org/10.1016/j.jacc.2007.01.082" @default.
• W2034379220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17498583" @default.
• W2034379220 hasPublicationYear "2007" @default.
• W2034379220 type Work @default.
• W2034379220 sameAs 2034379220 @default.
• W2034379220 citedByCount "32" @default.
• W2034379220 countsByYear W20343792202012 @default.
• W2034379220 countsByYear W20343792202013 @default.
• W2034379220 countsByYear W20343792202014 @default.
• W2034379220 countsByYear W20343792202019 @default.
• W2034379220 countsByYear W20343792202021 @default.
• W2034379220 countsByYear W20343792202023 @default.
• W2034379220 crossrefType "journal-article" @default.
• W2034379220 hasAuthorship W2034379220A5006406707 @default.
• W2034379220 hasAuthorship W2034379220A5022431115 @default.
• W2034379220 hasAuthorship W2034379220A5043544659 @default.
• W2034379220 hasAuthorship W2034379220A5071427601 @default.
• W2034379220 hasAuthorship W2034379220A5073298026 @default.
• W2034379220 hasAuthorship W2034379220A5078570290 @default.
• W2034379220 hasAuthorship W2034379220A5080359948 @default.
• W2034379220 hasAuthorship W2034379220A5081652370 @default.
• W2034379220 hasBestOaLocation W20343792201 @default.
• W2034379220 hasConcept C126322002 @default.
• W2034379220 hasConcept C134018914 @default.
• W2034379220 hasConcept C181199279 @default.
• W2034379220 hasConcept C185592680 @default.
• W2034379220 hasConcept C2776151105 @default.
• W2034379220 hasConcept C2777989768 @default.
• W2034379220 hasConcept C2781179581 @default.
• W2034379220 hasConcept C38485361 @default.
• W2034379220 hasConcept C55493867 @default.
• W2034379220 hasConcept C57600042 @default.
• W2034379220 hasConcept C71924100 @default.
• W2034379220 hasConceptScore W2034379220C126322002 @default.
• W2034379220 hasConceptScore W2034379220C134018914 @default.
• W2034379220 hasConceptScore W2034379220C181199279 @default.
• W2034379220 hasConceptScore W2034379220C185592680 @default.
• W2034379220 hasConceptScore W2034379220C2776151105 @default.
• W2034379220 hasConceptScore W2034379220C2777989768 @default.
• W2034379220 hasConceptScore W2034379220C2781179581 @default.
• W2034379220 hasConceptScore W2034379220C38485361 @default.
• W2034379220 hasConceptScore W2034379220C55493867 @default.
• W2034379220 hasConceptScore W2034379220C57600042 @default.
• W2034379220 hasConceptScore W2034379220C71924100 @default.
• W2034379220 hasIssue "19" @default.
• W2034379220 hasLocation W20343792201 @default.
• W2034379220 hasLocation W20343792202 @default.
• W2034379220 hasOpenAccess W2034379220 @default.
• W2034379220 hasPrimaryLocation W20343792201 @default.
• W2034379220 hasRelatedWork W2008336850 @default.
• W2034379220 hasRelatedWork W2029388560 @default.
• W2034379220 hasRelatedWork W2040379689 @default.

• next