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• W2034379333 abstract "The intracellular pathogen Anaplasma marginale (Rickettsiales: Anaplasmataceae), described by Sir Arnold Theiler in 1910, is endemic worldwide in tropical and subtropical areas. Infection of cattle with A. marginale causes bovine anaplasmosis, a mild to severe hemolytic disease that results in considerable economic loss to both dairy and beef industries. Transmission of A. marginale to cattle occurs biologically by ticks and mechanically by biting flies and by blood-contaminated fomites. Both male ticks and cattle hosts become persistently infected with A. marginale and serve as reservoirs of infection. While erythrocytes are the major site of infection in cattle, A. marginale undergoes a complex developmental cycle in ticks that begins by infection of gut cells, and transmission to susceptible hosts occurs from salivary glands during feeding. Major surface proteins (MSPs) play a crucial role in the interaction of A. marginale with host cells, and include adhesion proteins and MSPs from multigene families that undergo antigenic change and selection in cattle, thus contributing to maintenance of persistent infections. Many geographic strains of A. marginale have been identified worldwide, which vary in genotype, antigenic composition, morphology and infectivity for ticks. Isolates of A. marginale may be maintained by independent transmission events and a mechanism of infection/exclusion in cattle and ticks. The increasing numbers of A. marginale genotypes identified in some geographic regions most likely resulted from intensive cattle movement. However, concurrent A. marginale strain infections in cattle was reported, but these strains were more distantly related. Phylogenetic studies of selected geographic isolates of A. marginale, using msp4 and msp1α, provided information about the biogeography and evolution of A. marginale, and msp1α genotypes appear to have evolved under positive selection pressure. Live and killed vaccines have been used for control of anaplasmosis and both types of vaccines have advantages and disadvantages. Vaccines have effectively prevented clinical anaplasmosis in cattle but have failed to block A. marginale infection. Vaccines are needed that can prevent clinical disease and, simultaneously, prevent infection in cattle and ticks, thus eliminating these hosts as reservoirs of infection. Advances in genomics, proteomics, immunology and biochemical and molecular technologies during the last decade have been applied to research on A. marginale and related organisms, and the recent development of a cell culture system for A. marginale has provided a format for studying the pathogen/tick interface. Recent advancements and new research methodologies should provide additional opportunities for development of new strategies for control and prevention of bovine anaplasmosis." @default.
• W2034379333 created "2016-06-24" @default.
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• W2034379333 date "2010-02-01" @default.
• W2034379333 modified "2023-10-09" @default.
• W2034379333 title "The natural history of Anaplasma marginale" @default.
• W2034379333 cites W1494993959 @default.
• W2034379333 cites W1539116609 @default.
• W2034379333 cites W1858013354 @default.
• W2034379333 cites W1940694280 @default.
• W2034379333 cites W1946946176 @default.
• W2034379333 cites W1967808868 @default.
• W2034379333 cites W1969443505 @default.
• W2034379333 cites W1972642489 @default.
• W2034379333 cites W1975103068 @default.
• W2034379333 cites W1976036478 @default.
• W2034379333 cites W1978528421 @default.
• W2034379333 cites W1986186850 @default.
• W2034379333 cites W1988829912 @default.
• W2034379333 cites W1989469960 @default.
• W2034379333 cites W1990524557 @default.
• W2034379333 cites W1990690755 @default.
• W2034379333 cites W1993735906 @default.
• W2034379333 cites W1994192588 @default.
• W2034379333 cites W1997827390 @default.
• W2034379333 cites W1998631200 @default.
• W2034379333 cites W1999397315 @default.
• W2034379333 cites W2000189027 @default.
• W2034379333 cites W2013426625 @default.
• W2034379333 cites W2024392326 @default.
• W2034379333 cites W2026461769 @default.
• W2034379333 cites W2027558100 @default.
• W2034379333 cites W2028039100 @default.
• W2034379333 cites W2031374468 @default.
• W2034379333 cites W2034916436 @default.
• W2034379333 cites W2035487594 @default.
• W2034379333 cites W2038159286 @default.
• W2034379333 cites W2042045981 @default.
• W2034379333 cites W2042646685 @default.
• W2034379333 cites W2046643337 @default.
• W2034379333 cites W2060878109 @default.
• W2034379333 cites W2065350407 @default.
• W2034379333 cites W2065730802 @default.
• W2034379333 cites W2066894891 @default.
• W2034379333 cites W2068553742 @default.
• W2034379333 cites W2069340075 @default.
• W2034379333 cites W2072498877 @default.
• W2034379333 cites W2080294836 @default.
• W2034379333 cites W2080969718 @default.
• W2034379333 cites W2081018605 @default.
• W2034379333 cites W2089369243 @default.
• W2034379333 cites W2099016652 @default.
• W2034379333 cites W2100808143 @default.
• W2034379333 cites W2104402294 @default.
• W2034379333 cites W2112022810 @default.
• W2034379333 cites W2115765518 @default.
• W2034379333 cites W2115932590 @default.
• W2034379333 cites W2117144265 @default.
• W2034379333 cites W2119607597 @default.
• W2034379333 cites W2119892123 @default.
• W2034379333 cites W2124381185 @default.
• W2034379333 cites W2126860597 @default.
• W2034379333 cites W2128641524 @default.
• W2034379333 cites W2129892357 @default.
• W2034379333 cites W2130096080 @default.
• W2034379333 cites W2131184698 @default.
• W2034379333 cites W2132554048 @default.
• W2034379333 cites W2132889005 @default.
• W2034379333 cites W2134501568 @default.
• W2034379333 cites W2137207157 @default.
• W2034379333 cites W2140295614 @default.
• W2034379333 cites W2148844706 @default.
• W2034379333 cites W2155525691 @default.
• W2034379333 cites W2156385617 @default.
• W2034379333 cites W2165379126 @default.
• W2034379333 cites W2166460795 @default.
• W2034379333 cites W2170937018 @default.
• W2034379333 cites W2171779105 @default.
• W2034379333 cites W2172187342 @default.
• W2034379333 cites W2177102299 @default.
• W2034379333 cites W2177115517 @default.
• W2034379333 cites W2202378115 @default.
• W2034379333 cites W2219638600 @default.
• W2034379333 cites W2314481069 @default.
• W2034379333 cites W2316026204 @default.
• W2034379333 cites W2322506209 @default.
• W2034379333 cites W2323557000 @default.
• W2034379333 cites W2431906598 @default.
• W2034379333 cites W28688280 @default.
• W2034379333 cites W4254326059 @default.
• W2034379333 cites W4320801390 @default.
• W2034379333 cites W92083049 @default.
• W2034379333 doi "https://doi.org/10.1016/j.vetpar.2009.09.012" @default.
• W2034379333 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19811876" @default.

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