FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034379626> ?p ?o ?g. }

• W2034379626 endingPage "5388" @default.
• W2034379626 startingPage "5382" @default.
• W2034379626 abstract "Post-translational modifications by the Small Ubiquitin-like Modifier (SUMO) family of proteins have been established as critical events in the cellular response to a wide range of DNA damaging reagents and radiation; however, the detailed mechanism of SUMOylation in DNA damage response is not well understood. In this study, we used a nuclear magnetic resonance (NMR) spectroscopy-based metabolomics approach to examine the effect of an inhibitor of SUMO-mediated protein-protein interactions on MCF7 breast cancer cell response to radiation. Metabolomics is sensitive to changes in cellular functions and thus provides complementary information to other biological studies. The peptide inhibitor (SUMO interaction motif mimic, SIM) and a control peptide were stably expressed in MCF-7 cell line. Metabolite profiles of the cell lines before and after radiation were analyzed using solution NMR methods. Various statistical methods were used to isolate significant changes. Differences in the amounts of glutamine, aspartate, malate, alanine, glutamate and NADH between the SIM-expressing and control cells suggest a role for SUMOylation in regulating mitochondrial function. This is also further verified following the metabolism of (13)C-labeled glutamine. The inability of the cells expressing the SIM peptide to increase production of the antioxidants carnosine and glutathione after radiation damage suggests an important role of SUMOylation in regulating the levels of antioxidants that protect cells from free radicals and reactive oxygen species generated by radiation. This study reveals previously unknown roles of SUMOylation in DNA damage response." @default.
• W2034379626 created "2016-06-24" @default.
• W2034379626 creator A5052134746 @default.
• W2034379626 creator A5067750617 @default.
• W2034379626 creator A5079883319 @default.
• W2034379626 date "2010-08-09" @default.
• W2034379626 modified "2023-09-26" @default.
• W2034379626 title "NMR Metabolomic Profiling Reveals New Roles of SUMOylation in DNA Damage Response" @default.
• W2034379626 cites W1600888450 @default.
• W2034379626 cites W1967707683 @default.
• W2034379626 cites W1968813633 @default.
• W2034379626 cites W1968914483 @default.
• W2034379626 cites W1974402979 @default.
• W2034379626 cites W1976767543 @default.
• W2034379626 cites W1976880272 @default.
• W2034379626 cites W1989643386 @default.
• W2034379626 cites W1992363628 @default.
• W2034379626 cites W2009128158 @default.
• W2034379626 cites W2014869787 @default.
• W2034379626 cites W2015925058 @default.
• W2034379626 cites W2017626786 @default.
• W2034379626 cites W2021044341 @default.
• W2034379626 cites W2022439334 @default.
• W2034379626 cites W2022501326 @default.
• W2034379626 cites W2028240481 @default.
• W2034379626 cites W2030575063 @default.
• W2034379626 cites W2032545721 @default.
• W2034379626 cites W2048370637 @default.
• W2034379626 cites W2049262839 @default.
• W2034379626 cites W2052289985 @default.
• W2034379626 cites W2053385401 @default.
• W2034379626 cites W2054782539 @default.
• W2034379626 cites W2055486023 @default.
• W2034379626 cites W2068542211 @default.
• W2034379626 cites W2073534270 @default.
• W2034379626 cites W2075887449 @default.
• W2034379626 cites W2076217757 @default.
• W2034379626 cites W2087786655 @default.
• W2034379626 cites W2089677512 @default.
• W2034379626 cites W2095208614 @default.
• W2034379626 cites W2099017922 @default.
• W2034379626 cites W2099167252 @default.
• W2034379626 cites W2100419900 @default.
• W2034379626 cites W2110725112 @default.
• W2034379626 cites W2119653500 @default.
• W2034379626 cites W2132889938 @default.
• W2034379626 cites W2140138777 @default.
• W2034379626 cites W2152311269 @default.
• W2034379626 cites W2168607632 @default.
• W2034379626 cites W2322053818 @default.
• W2034379626 doi "https://doi.org/10.1021/pr100614a" @default.
• W2034379626 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2954278" @default.
• W2034379626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20695451" @default.
• W2034379626 hasPublicationYear "2010" @default.
• W2034379626 type Work @default.
• W2034379626 sameAs 2034379626 @default.
• W2034379626 citedByCount "17" @default.
• W2034379626 countsByYear W20343796262012 @default.
• W2034379626 countsByYear W20343796262013 @default.
• W2034379626 countsByYear W20343796262014 @default.
• W2034379626 countsByYear W20343796262015 @default.
• W2034379626 countsByYear W20343796262016 @default.
• W2034379626 countsByYear W20343796262018 @default.
• W2034379626 crossrefType "journal-article" @default.
• W2034379626 hasAuthorship W2034379626A5052134746 @default.
• W2034379626 hasAuthorship W2034379626A5067750617 @default.
• W2034379626 hasAuthorship W2034379626A5079883319 @default.
• W2034379626 hasBestOaLocation W20343796262 @default.
• W2034379626 hasConcept C104317684 @default.
• W2034379626 hasConcept C143425029 @default.
• W2034379626 hasConcept C171350616 @default.
• W2034379626 hasConcept C185592680 @default.
• W2034379626 hasConcept C21565614 @default.
• W2034379626 hasConcept C25602115 @default.
• W2034379626 hasConcept C2776016237 @default.
• W2034379626 hasConcept C2779281246 @default.
• W2034379626 hasConcept C2779349466 @default.
• W2034379626 hasConcept C2779856020 @default.
• W2034379626 hasConcept C515207424 @default.
• W2034379626 hasConcept C552990157 @default.
• W2034379626 hasConcept C55493867 @default.
• W2034379626 hasConcept C60644358 @default.
• W2034379626 hasConcept C86803240 @default.
• W2034379626 hasConcept C95444343 @default.
• W2034379626 hasConceptScore W2034379626C104317684 @default.
• W2034379626 hasConceptScore W2034379626C143425029 @default.
• W2034379626 hasConceptScore W2034379626C171350616 @default.
• W2034379626 hasConceptScore W2034379626C185592680 @default.
• W2034379626 hasConceptScore W2034379626C21565614 @default.
• W2034379626 hasConceptScore W2034379626C25602115 @default.
• W2034379626 hasConceptScore W2034379626C2776016237 @default.
• W2034379626 hasConceptScore W2034379626C2779281246 @default.
• W2034379626 hasConceptScore W2034379626C2779349466 @default.
• W2034379626 hasConceptScore W2034379626C2779856020 @default.
• W2034379626 hasConceptScore W2034379626C515207424 @default.
• W2034379626 hasConceptScore W2034379626C552990157 @default.
• W2034379626 hasConceptScore W2034379626C55493867 @default.
• W2034379626 hasConceptScore W2034379626C60644358 @default.

• next