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• W2034380071 startingPage "803" @default.
• W2034380071 abstract "Upregulation of extracellular chondroitin sulfate proteoglycans (CSPG) is a primary cause for the failure of axons to regenerate after spinal cord injury (SCI), and the beneficial effect of their degradation by chondroitinase ABC (ChABC) is widely documented. Little is known, however, about the effect of ChABC treatment on astrogliosis and revascularization, two important factors influencing axon regrowth. This was investigated in the present study. Immediately after a spinal cord hemisection at thoracic level 8-9, we injected ChABC intrathecally at the sacral level, repeated three times until 10 days post-injury. Our results show an effective cleavage of CSPG glycosaminoglycan chains and stimulation of axonal remodeling within the injury site, accompanied by an extended period of astrocyte remodeling (up to 4 weeks). Interestingly, ChABC treatment favored an orientation of astrocytic processes directed toward the injury, in close association with axons at the lesion entry zone, suggesting a correlation between axon and astrocyte remodeling. Further, during the first weeks post-injury, ChABC treatment affected the morphology of laminin-positive blood vessel basement membranes and vessel-independent laminin deposits: hypertrophied blood vessels with detached or duplicated basement membrane were more numerous than in lesioned untreated animals. In contrast, at later time points, laminin expression increased and became more directly associated with newly formed blood vessels, the size of which tended to be closer to that found in intact tissue. Our data reinforce the idea that ChABC injection in combination with other synergistic treatments is a promising therapeutic strategy for SCI repair." @default.
• W2034380071 created "2016-06-24" @default.
• W2034380071 creator A5029054194 @default.
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• W2034380071 creator A5079617712 @default.
• W2034380071 creator A5083181208 @default.
• W2034380071 date "2014-05-01" @default.
• W2034380071 modified "2023-10-16" @default.
• W2034380071 title "Astrocytic and Vascular Remodeling in the Injured Adult Rat Spinal Cord after Chondroitinase ABC Treatment" @default.
• W2034380071 cites W1571975997 @default.
• W2034380071 cites W1723871640 @default.
• W2034380071 cites W1760881456 @default.
• W2034380071 cites W1966007526 @default.
• W2034380071 cites W1966505684 @default.
• W2034380071 cites W1968758791 @default.
• W2034380071 cites W1969619562 @default.
• W2034380071 cites W1971975196 @default.
• W2034380071 cites W1972490216 @default.
• W2034380071 cites W1973485004 @default.
• W2034380071 cites W1976281715 @default.
• W2034380071 cites W1976624762 @default.
• W2034380071 cites W1983216462 @default.
• W2034380071 cites W1983410669 @default.
• W2034380071 cites W1985993123 @default.
• W2034380071 cites W1994049385 @default.
• W2034380071 cites W1998260405 @default.
• W2034380071 cites W1998483724 @default.
• W2034380071 cites W1999941576 @default.
• W2034380071 cites W2003613899 @default.
• W2034380071 cites W2005378461 @default.
• W2034380071 cites W2006560625 @default.
• W2034380071 cites W2012928251 @default.
• W2034380071 cites W2013213603 @default.
• W2034380071 cites W2016820608 @default.
• W2034380071 cites W2017937302 @default.
• W2034380071 cites W2024599421 @default.
• W2034380071 cites W2025053467 @default.
• W2034380071 cites W2025221884 @default.
• W2034380071 cites W2025851321 @default.
• W2034380071 cites W2026362430 @default.
• W2034380071 cites W2028717305 @default.
• W2034380071 cites W2029527028 @default.
• W2034380071 cites W2030491608 @default.
• W2034380071 cites W2030662122 @default.
• W2034380071 cites W2030927825 @default.
• W2034380071 cites W2034597638 @default.
• W2034380071 cites W2038881167 @default.
• W2034380071 cites W2040022930 @default.
• W2034380071 cites W2041860929 @default.
• W2034380071 cites W2054627021 @default.
• W2034380071 cites W2056024566 @default.
• W2034380071 cites W2057819786 @default.
• W2034380071 cites W2059493571 @default.
• W2034380071 cites W2060111610 @default.
• W2034380071 cites W2063535670 @default.
• W2034380071 cites W2063571042 @default.
• W2034380071 cites W2064009495 @default.
• W2034380071 cites W2066487839 @default.
• W2034380071 cites W2067978052 @default.
• W2034380071 cites W2068479857 @default.
• W2034380071 cites W2069273217 @default.
• W2034380071 cites W2069329007 @default.
• W2034380071 cites W2069504501 @default.
• W2034380071 cites W2078266056 @default.
• W2034380071 cites W2085424855 @default.
• W2034380071 cites W2085482903 @default.
• W2034380071 cites W2085752138 @default.
• W2034380071 cites W2086892345 @default.
• W2034380071 cites W2087251720 @default.
• W2034380071 cites W2089909243 @default.
• W2034380071 cites W2097530133 @default.
• W2034380071 cites W2098974321 @default.
• W2034380071 cites W2101233757 @default.
• W2034380071 cites W2101667799 @default.
• W2034380071 cites W2101957440 @default.
• W2034380071 cites W2104968232 @default.
• W2034380071 cites W2109360045 @default.
• W2034380071 cites W2115961895 @default.
• W2034380071 cites W2116881591 @default.
• W2034380071 cites W2118427313 @default.
• W2034380071 cites W2124085296 @default.
• W2034380071 cites W2126017421 @default.
• W2034380071 cites W2130639482 @default.
• W2034380071 cites W2135376726 @default.
• W2034380071 cites W2141244009 @default.
• W2034380071 cites W2141826410 @default.
• W2034380071 cites W2144351874 @default.
• W2034380071 cites W2145049266 @default.
• W2034380071 cites W2151201303 @default.
• W2034380071 cites W2167208176 @default.
• W2034380071 cites W2167279371 @default.
• W2034380071 cites W2170907699 @default.
• W2034380071 cites W223795620 @default.
• W2034380071 cites W2335339546 @default.
• W2034380071 cites W3355293 @default.
• W2034380071 doi "https://doi.org/10.1089/neu.2013.3143" @default.
• W2034380071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3996996" @default.

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