FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034381565> ?p ?o ?g. }

• W2034381565 abstract "Dental pulp stem cells (DPSCs) can be driven into odontoblast, osteoblast, and chondrocyte lineages in different inductive media. However, the differentiation potential of naive DPSCs after serial passaging in the routine culture system has not been fully elucidated. DPSCs were isolated from human/rat dental pulps by the magnetic activated cell sorting based on STRO-1 expression, cultured and passaged in the conventional culture media. The biological features of STRO-1+ DPSCs at the 1st and 9th passages were investigated. During the long-term passage, the proliferation ability of human STRO-1+ DPSCs was downregulated as indicated by the growth kinetics. When compared with STRO-1+ DPSCs at the 1st passage (DPSC-P1), the expression of mature osteoblast-specific genes/proteins (alkaline phosphatase, bone sialoprotein, osterix, and osteopontin), odontoblast-specific gene/protein (dentin sialophosphoprotein and dentin sialoprotein), and chondrocyte-specific gene/protein (type II collagen) was significantly upregulated in human STRO-1+ DPSCs at the 9th passage (DPSC-P9). Furthermore, human DPSC-P9 cells in the mineralization-inducing media presented higher levels of alkaline phosphatase at day 3 and day 7 respectively, and produced more mineralized matrix than DPSC-P9 cells at day 14. In vivo transplantation results showed that rat DPSC-P1 cell pellets developed into dentin, bone and cartilage structures respectively, while DPSC-P9 cells can only generate bone tissues. These findings suggest that STRO-1+ DPSCs consist of several interrelated subpopulations which can spontaneously differentiate into odontoblasts, osteoblasts, and chondrocytes. The differentiation capacity of these DPSCs changes during cell passaging, and DPSCs at the 9th passage restrict their differentiation potential to the osteoblast lineage in vivo." @default.
• W2034381565 created "2016-06-24" @default.
• W2034381565 creator A5011014503 @default.
• W2034381565 creator A5033517658 @default.
• W2034381565 creator A5036060043 @default.
• W2034381565 creator A5041891687 @default.
• W2034381565 creator A5061808496 @default.
• W2034381565 creator A5062400152 @default.
• W2034381565 creator A5074630211 @default.
• W2034381565 creator A5078535250 @default.
• W2034381565 date "2010-05-08" @default.
• W2034381565 modified "2023-10-16" @default.
• W2034381565 title "Differentiation potential of STRO-1+ dental pulp stem cells changes during cell passaging" @default.
• W2034381565 cites W1552240535 @default.
• W2034381565 cites W1561427403 @default.
• W2034381565 cites W1574990684 @default.
• W2034381565 cites W1965566799 @default.
• W2034381565 cites W1965822270 @default.
• W2034381565 cites W1976102072 @default.
• W2034381565 cites W1977164279 @default.
• W2034381565 cites W1977203616 @default.
• W2034381565 cites W1983091320 @default.
• W2034381565 cites W1991382572 @default.
• W2034381565 cites W2015725078 @default.
• W2034381565 cites W2017427578 @default.
• W2034381565 cites W2027012204 @default.
• W2034381565 cites W2039035015 @default.
• W2034381565 cites W2051727544 @default.
• W2034381565 cites W2066749058 @default.
• W2034381565 cites W2073948335 @default.
• W2034381565 cites W2074624875 @default.
• W2034381565 cites W2112127540 @default.
• W2034381565 cites W2113764168 @default.
• W2034381565 cites W2130516299 @default.
• W2034381565 cites W2136767600 @default.
• W2034381565 cites W2145040826 @default.
• W2034381565 cites W2151955120 @default.
• W2034381565 cites W2163404165 @default.
• W2034381565 cites W2165238834 @default.
• W2034381565 cites W2217100198 @default.
• W2034381565 doi "https://doi.org/10.1186/1471-2121-11-32" @default.
• W2034381565 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2877667" @default.
• W2034381565 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20459680" @default.
• W2034381565 hasPublicationYear "2010" @default.
• W2034381565 type Work @default.
• W2034381565 sameAs 2034381565 @default.
• W2034381565 citedByCount "166" @default.
• W2034381565 countsByYear W20343815652012 @default.
• W2034381565 countsByYear W20343815652013 @default.
• W2034381565 countsByYear W20343815652014 @default.
• W2034381565 countsByYear W20343815652015 @default.
• W2034381565 countsByYear W20343815652016 @default.
• W2034381565 countsByYear W20343815652017 @default.
• W2034381565 countsByYear W20343815652018 @default.
• W2034381565 countsByYear W20343815652019 @default.
• W2034381565 countsByYear W20343815652020 @default.
• W2034381565 countsByYear W20343815652021 @default.
• W2034381565 countsByYear W20343815652022 @default.
• W2034381565 countsByYear W20343815652023 @default.
• W2034381565 crossrefType "journal-article" @default.
• W2034381565 hasAuthorship W2034381565A5011014503 @default.
• W2034381565 hasAuthorship W2034381565A5033517658 @default.
• W2034381565 hasAuthorship W2034381565A5036060043 @default.
• W2034381565 hasAuthorship W2034381565A5041891687 @default.
• W2034381565 hasAuthorship W2034381565A5061808496 @default.
• W2034381565 hasAuthorship W2034381565A5062400152 @default.
• W2034381565 hasAuthorship W2034381565A5074630211 @default.
• W2034381565 hasAuthorship W2034381565A5078535250 @default.
• W2034381565 hasBestOaLocation W20343815651 @default.
• W2034381565 hasConcept C105702510 @default.
• W2034381565 hasConcept C131075544 @default.
• W2034381565 hasConcept C142724271 @default.
• W2034381565 hasConcept C160160445 @default.
• W2034381565 hasConcept C181199279 @default.
• W2034381565 hasConcept C185592680 @default.
• W2034381565 hasConcept C202751555 @default.
• W2034381565 hasConcept C203014093 @default.
• W2034381565 hasConcept C2520015 @default.
• W2034381565 hasConcept C2522874641 @default.
• W2034381565 hasConcept C2776432469 @default.
• W2034381565 hasConcept C2777267240 @default.
• W2034381565 hasConcept C2777400515 @default.
• W2034381565 hasConcept C2778260815 @default.
• W2034381565 hasConcept C2779203663 @default.
• W2034381565 hasConcept C2779263046 @default.
• W2034381565 hasConcept C2780550940 @default.
• W2034381565 hasConcept C2780804394 @default.
• W2034381565 hasConcept C2781403057 @default.
• W2034381565 hasConcept C28328180 @default.
• W2034381565 hasConcept C55493867 @default.
• W2034381565 hasConcept C68434959 @default.
• W2034381565 hasConcept C71924100 @default.
• W2034381565 hasConcept C86803240 @default.
• W2034381565 hasConcept C95444343 @default.
• W2034381565 hasConceptScore W2034381565C105702510 @default.
• W2034381565 hasConceptScore W2034381565C131075544 @default.
• W2034381565 hasConceptScore W2034381565C142724271 @default.
• W2034381565 hasConceptScore W2034381565C160160445 @default.
• W2034381565 hasConceptScore W2034381565C181199279 @default.
• W2034381565 hasConceptScore W2034381565C185592680 @default.

• next