Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034382007> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2034382007 endingPage "816" @default.
- W2034382007 startingPage "812" @default.
- W2034382007 abstract "G protein-coupled receptors (GPCRs) can be activated by multiple ligands and exhibit the capacity to couple to numerous intracellular signal transduction pathways. This property allows GPCRs to be modulated by biased agonists that selectively activate specific subsets of GPCR-regulated cellular signaling proteins. The angiotensin II type 1 receptor (AT1R) is a GPCR that endogenously binds to the peptide ligand angiotensin II. More recently it has been demonstrated that a modified peptide, [Sar1I-le4-Ile8]-angiotensin II (SII) acts as a biased agonist towards the AT1R. SII binds to the AT1R without promoting heterotrimeric G protein-coupling, but serves to link the receptor to the beta-arrestin-dependent activation of the mitogen activated protein kinase pathway. The present mini-review summarizes current knowledge regarding the role of biased agonists in stimulating biased AT1R signaling." @default.
- W2034382007 created "2016-06-24" @default.
- W2034382007 creator A5045085436 @default.
- W2034382007 creator A5055889724 @default.
- W2034382007 date "2012-06-01" @default.
- W2034382007 modified "2023-10-14" @default.
- W2034382007 title "Biased Agonism of the Angiotensin II Type 1 Receptor" @default.
- W2034382007 doi "https://doi.org/10.2174/138955712800959134" @default.
- W2034382007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22681254" @default.
- W2034382007 hasPublicationYear "2012" @default.
- W2034382007 type Work @default.
- W2034382007 sameAs 2034382007 @default.
- W2034382007 citedByCount "27" @default.
- W2034382007 countsByYear W20343820072013 @default.
- W2034382007 countsByYear W20343820072014 @default.
- W2034382007 countsByYear W20343820072015 @default.
- W2034382007 countsByYear W20343820072016 @default.
- W2034382007 countsByYear W20343820072017 @default.
- W2034382007 countsByYear W20343820072018 @default.
- W2034382007 countsByYear W20343820072019 @default.
- W2034382007 countsByYear W20343820072020 @default.
- W2034382007 countsByYear W20343820072022 @default.
- W2034382007 countsByYear W20343820072023 @default.
- W2034382007 crossrefType "journal-article" @default.
- W2034382007 hasAuthorship W2034382007A5045085436 @default.
- W2034382007 hasAuthorship W2034382007A5055889724 @default.
- W2034382007 hasConcept C135285700 @default.
- W2034382007 hasConcept C139407321 @default.
- W2034382007 hasConcept C170493617 @default.
- W2034382007 hasConcept C184235292 @default.
- W2034382007 hasConcept C185592680 @default.
- W2034382007 hasConcept C2777503648 @default.
- W2034382007 hasConcept C2778938600 @default.
- W2034382007 hasConcept C2908929049 @default.
- W2034382007 hasConcept C33235085 @default.
- W2034382007 hasConcept C43587935 @default.
- W2034382007 hasConcept C55493867 @default.
- W2034382007 hasConcept C62478195 @default.
- W2034382007 hasConcept C80631254 @default.
- W2034382007 hasConcept C86803240 @default.
- W2034382007 hasConcept C95444343 @default.
- W2034382007 hasConcept C97029542 @default.
- W2034382007 hasConceptScore W2034382007C135285700 @default.
- W2034382007 hasConceptScore W2034382007C139407321 @default.
- W2034382007 hasConceptScore W2034382007C170493617 @default.
- W2034382007 hasConceptScore W2034382007C184235292 @default.
- W2034382007 hasConceptScore W2034382007C185592680 @default.
- W2034382007 hasConceptScore W2034382007C2777503648 @default.
- W2034382007 hasConceptScore W2034382007C2778938600 @default.
- W2034382007 hasConceptScore W2034382007C2908929049 @default.
- W2034382007 hasConceptScore W2034382007C33235085 @default.
- W2034382007 hasConceptScore W2034382007C43587935 @default.
- W2034382007 hasConceptScore W2034382007C55493867 @default.
- W2034382007 hasConceptScore W2034382007C62478195 @default.
- W2034382007 hasConceptScore W2034382007C80631254 @default.
- W2034382007 hasConceptScore W2034382007C86803240 @default.
- W2034382007 hasConceptScore W2034382007C95444343 @default.
- W2034382007 hasConceptScore W2034382007C97029542 @default.
- W2034382007 hasIssue "9" @default.
- W2034382007 hasLocation W20343820071 @default.
- W2034382007 hasLocation W20343820072 @default.
- W2034382007 hasOpenAccess W2034382007 @default.
- W2034382007 hasPrimaryLocation W20343820071 @default.
- W2034382007 hasRelatedWork W1599069035 @default.
- W2034382007 hasRelatedWork W2044762993 @default.
- W2034382007 hasRelatedWork W2111535188 @default.
- W2034382007 hasRelatedWork W2117762969 @default.
- W2034382007 hasRelatedWork W2301315961 @default.
- W2034382007 hasRelatedWork W2479584601 @default.
- W2034382007 hasRelatedWork W3176096134 @default.
- W2034382007 hasRelatedWork W4210440837 @default.
- W2034382007 hasRelatedWork W4221044813 @default.
- W2034382007 hasRelatedWork W4226502462 @default.
- W2034382007 hasVolume "12" @default.
- W2034382007 isParatext "false" @default.
- W2034382007 isRetracted "false" @default.
- W2034382007 magId "2034382007" @default.
- W2034382007 workType "article" @default.