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• W2034382130 abstract "Radioimmunoassay techniques have been employed to measure the endogenous concentration of testosterone (T) and dihydrotestosterone (DHT) within the plasma, seminal vesicle epithelium (SVE), seminal vesicle muscle (SVM), prostate gland (P), and other tissues of mature male guinea pigs. Additional studies have been performed comparing both the in vivo and in vitro distribution and metabolism of tritiated testosterone within these same tissues. The endogenous concentration of T and DHT within the sex accessory organs and plasma was determined to be as follows: SVE: (DHT = 12.31 ± 0.57, T = 3.29 ± 0.44pg/mg), SVM: (DHT = 4.37 ± 0.56, T = 4.33 ± 0.37 pg/mg), P:(DHT = 7.19 ± 1.34, T = 3.83 ± 0.51 pg/mg), and plasma: (DHT = 1.8 ± 0.13, T = 4.41 ± 0.31 pg/mg). Further studies revealed that, with the exception of steroidogenic tissues (adrenal and testis), a good correlation appears to exist between a tissue's capacity to form and retain [3H]-DHT either in vivo or in vitro, and the endogenous content of DHT quantified within. This study demonstrates the selective capacity of the sex accessory gland epithelium as well as the sex accessory gland muscle to concentrate endogenous androgen from plasma, and that this capacity to do so appears to be determined, at least in part, by the selective ability to form and retain DHT." @default.
• W2034382130 created "2016-06-24" @default.
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• W2034382130 date "1977-08-01" @default.
• W2034382130 modified "2023-09-25" @default.
• W2034382130 title "Quantification of endogenous testosterone and dihydrotestosterone and their possible intracellular determinants in various tissues of the male guinea pig" @default.
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• W2034382130 doi "https://doi.org/10.1016/0022-4731(77)90087-5" @default.
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