Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034382238> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2034382238 abstract "A series of novel C11-substituted derivatives of azaelliptitoxin (azatoxin) have been synthesized and tested for their inhibitory activity against human DNA topoisomerase II. Incorporation of a C11 polyamine or amine resulted in an increase in the intercalation properties of the drug and a decrease of topoisomerase II activity. The structure-activity relationship (SAR) profile of the nonintercalating C11 anilino azatoxin class follows the SAR of the (anilino)acridine family. 11-(4-Cyanoanilino)azatoxin (14) was found to be the most active analog in this series, exhibiting approximately 10-fold higher activity than azatoxin 12 and etoposide." @default.
- W2034382238 created "2016-06-24" @default.
- W2034382238 creator A5008742393 @default.
- W2034382238 creator A5012762190 @default.
- W2034382238 creator A5018679472 @default.
- W2034382238 creator A5057402374 @default.
- W2034382238 creator A5059724481 @default.
- W2034382238 creator A5087139970 @default.
- W2034382238 date "2010-08-05" @default.
- W2034382238 modified "2023-09-27" @default.
- W2034382238 title "ChemInform Abstract: Inhibition of DNA Topoisomerase II by Azaelliptitoxins Functionalized in the Variable Substituent Domain." @default.
- W2034382238 cites W2953333383 @default.
- W2034382238 doi "https://doi.org/10.1002/chin.199637203" @default.
- W2034382238 hasPublicationYear "2010" @default.
- W2034382238 type Work @default.
- W2034382238 sameAs 2034382238 @default.
- W2034382238 citedByCount "0" @default.
- W2034382238 crossrefType "journal-article" @default.
- W2034382238 hasAuthorship W2034382238A5008742393 @default.
- W2034382238 hasAuthorship W2034382238A5012762190 @default.
- W2034382238 hasAuthorship W2034382238A5018679472 @default.
- W2034382238 hasAuthorship W2034382238A5057402374 @default.
- W2034382238 hasAuthorship W2034382238A5059724481 @default.
- W2034382238 hasAuthorship W2034382238A5087139970 @default.
- W2034382238 hasConcept C131779359 @default.
- W2034382238 hasConcept C137824038 @default.
- W2034382238 hasConcept C141071460 @default.
- W2034382238 hasConcept C147897179 @default.
- W2034382238 hasConcept C178790620 @default.
- W2034382238 hasConcept C185592680 @default.
- W2034382238 hasConcept C2776694085 @default.
- W2034382238 hasConcept C2776924795 @default.
- W2034382238 hasConcept C2778119113 @default.
- W2034382238 hasConcept C2778689049 @default.
- W2034382238 hasConcept C552990157 @default.
- W2034382238 hasConcept C55493867 @default.
- W2034382238 hasConcept C71240020 @default.
- W2034382238 hasConcept C71924100 @default.
- W2034382238 hasConceptScore W2034382238C131779359 @default.
- W2034382238 hasConceptScore W2034382238C137824038 @default.
- W2034382238 hasConceptScore W2034382238C141071460 @default.
- W2034382238 hasConceptScore W2034382238C147897179 @default.
- W2034382238 hasConceptScore W2034382238C178790620 @default.
- W2034382238 hasConceptScore W2034382238C185592680 @default.
- W2034382238 hasConceptScore W2034382238C2776694085 @default.
- W2034382238 hasConceptScore W2034382238C2776924795 @default.
- W2034382238 hasConceptScore W2034382238C2778119113 @default.
- W2034382238 hasConceptScore W2034382238C2778689049 @default.
- W2034382238 hasConceptScore W2034382238C552990157 @default.
- W2034382238 hasConceptScore W2034382238C55493867 @default.
- W2034382238 hasConceptScore W2034382238C71240020 @default.
- W2034382238 hasConceptScore W2034382238C71924100 @default.
- W2034382238 hasLocation W20343822381 @default.
- W2034382238 hasOpenAccess W2034382238 @default.
- W2034382238 hasPrimaryLocation W20343822381 @default.
- W2034382238 hasRelatedWork W2041952697 @default.
- W2034382238 hasRelatedWork W2043569527 @default.
- W2034382238 hasRelatedWork W2072087389 @default.
- W2034382238 hasRelatedWork W2111047350 @default.
- W2034382238 hasRelatedWork W2115530210 @default.
- W2034382238 hasRelatedWork W2792629566 @default.
- W2034382238 hasRelatedWork W2793035104 @default.
- W2034382238 hasRelatedWork W2909360454 @default.
- W2034382238 hasRelatedWork W2913776155 @default.
- W2034382238 hasRelatedWork W2949873485 @default.
- W2034382238 hasRelatedWork W2950641137 @default.
- W2034382238 hasRelatedWork W2951695859 @default.
- W2034382238 hasRelatedWork W2951806191 @default.
- W2034382238 hasRelatedWork W2952400193 @default.
- W2034382238 hasRelatedWork W2952696976 @default.
- W2034382238 hasRelatedWork W2998266012 @default.
- W2034382238 hasRelatedWork W3034999189 @default.
- W2034382238 hasRelatedWork W3093010178 @default.
- W2034382238 hasRelatedWork W3141559382 @default.
- W2034382238 hasRelatedWork W2998856574 @default.
- W2034382238 isParatext "false" @default.
- W2034382238 isRetracted "false" @default.
- W2034382238 magId "2034382238" @default.
- W2034382238 workType "article" @default.