FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034382342> ?p ?o ?g. }

• W2034382342 endingPage "1966" @default.
• W2034382342 startingPage "1959" @default.
• W2034382342 abstract "Background In 1999, avian influenza A/Hong Kong/1073/99 (H9N2) virus emerged as a pandemic threat to human beings. We aimed to assess safety, tolerability, and antigenicity of whole virus and subunit H9N2 vaccines in healthy volunteers. Methods In a phase I randomised trial we randomly assigned 60 participants to whole virus or subunit H9N2 vaccine. Two doses of 7·5 μg, 15 μg, or 30 μg haemagglutinin influenza A H9N2 vaccine, were given 3 weeks apart. We measured antibody responses by haemagglutination-inhibition and microneutralisation. The primary outcome was geometric mean antibody titre 21 days after vaccination. Analysis was per protocol. Findings Both vaccines were safe and well tolerated. The antibody titres after vaccination did not differ significantly between subunit and whole virus vaccine. 24 of 60 prevaccination serum samples had unexpected reactivity to H9N2, but only in participants older than 32 years, in whom one dose of either vaccine evoked antibody responses associated with protection. In participants aged 32 years or younger, antibody responses to one dose of whole virus or subunit vaccine were poor, fulfilling none of the criteria used for yearly relicensing of interpandemic vaccines. Whole virus vaccine produced a significantly higher probability of seroconversion compared with subunit virus for this age-group. Interpretation In immunologically naive patients whole-virus vaccine produced better responses than subunit vaccine. Two doses of subunit or whole virus vaccine would leave a large proportion of the naive population (⩽32 years) unprotected against A/Hong Kong/1073/99 (H9N2). Primed patients should be protected with a single dose of either vaccine. In 1999, avian influenza A/Hong Kong/1073/99 (H9N2) virus emerged as a pandemic threat to human beings. We aimed to assess safety, tolerability, and antigenicity of whole virus and subunit H9N2 vaccines in healthy volunteers. In a phase I randomised trial we randomly assigned 60 participants to whole virus or subunit H9N2 vaccine. Two doses of 7·5 μg, 15 μg, or 30 μg haemagglutinin influenza A H9N2 vaccine, were given 3 weeks apart. We measured antibody responses by haemagglutination-inhibition and microneutralisation. The primary outcome was geometric mean antibody titre 21 days after vaccination. Analysis was per protocol. Both vaccines were safe and well tolerated. The antibody titres after vaccination did not differ significantly between subunit and whole virus vaccine. 24 of 60 prevaccination serum samples had unexpected reactivity to H9N2, but only in participants older than 32 years, in whom one dose of either vaccine evoked antibody responses associated with protection. In participants aged 32 years or younger, antibody responses to one dose of whole virus or subunit vaccine were poor, fulfilling none of the criteria used for yearly relicensing of interpandemic vaccines. Whole virus vaccine produced a significantly higher probability of seroconversion compared with subunit virus for this age-group. In immunologically naive patients whole-virus vaccine produced better responses than subunit vaccine. Two doses of subunit or whole virus vaccine would leave a large proportion of the naive population (⩽32 years) unprotected against A/Hong Kong/1073/99 (H9N2). Primed patients should be protected with a single dose of either vaccine." @default.
• W2034382342 created "2016-06-24" @default.
• W2034382342 creator A5016759298 @default.
• W2034382342 creator A5031412427 @default.
• W2034382342 creator A5033012154 @default.
• W2034382342 creator A5045004136 @default.
• W2034382342 creator A5053396770 @default.
• W2034382342 creator A5055194670 @default.
• W2034382342 creator A5055565095 @default.
• W2034382342 creator A5079845981 @default.
• W2034382342 creator A5080194386 @default.
• W2034382342 creator A5080592111 @default.
• W2034382342 date "2003-12-01" @default.
• W2034382342 modified "2023-09-27" @default.
• W2034382342 title "Safety and antigenicity of whole virus and subunit influenza A/Hong Kong/1073/99 (H9N2) vaccine in healthy adults: phase I randomised trial" @default.
• W2034382342 cites W1499536593 @default.
• W2034382342 cites W1969287126 @default.
• W2034382342 cites W1975145532 @default.
• W2034382342 cites W2004139298 @default.
• W2034382342 cites W2036596307 @default.
• W2034382342 cites W2059497826 @default.
• W2034382342 cites W2085736050 @default.
• W2034382342 cites W2087508560 @default.
• W2034382342 cites W2092097938 @default.
• W2034382342 cites W2118110185 @default.
• W2034382342 cites W2126309815 @default.
• W2034382342 cites W2148734478 @default.
• W2034382342 cites W2155467153 @default.
• W2034382342 cites W42629814 @default.
• W2034382342 doi "https://doi.org/10.1016/s0140-6736(03)15014-3" @default.
• W2034382342 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14683655" @default.
• W2034382342 hasPublicationYear "2003" @default.
• W2034382342 type Work @default.
• W2034382342 sameAs 2034382342 @default.
• W2034382342 citedByCount "134" @default.
• W2034382342 countsByYear W20343823422012 @default.
• W2034382342 countsByYear W20343823422013 @default.
• W2034382342 countsByYear W20343823422014 @default.
• W2034382342 countsByYear W20343823422015 @default.
• W2034382342 countsByYear W20343823422016 @default.
• W2034382342 countsByYear W20343823422017 @default.
• W2034382342 countsByYear W20343823422018 @default.
• W2034382342 countsByYear W20343823422019 @default.
• W2034382342 countsByYear W20343823422020 @default.
• W2034382342 countsByYear W20343823422021 @default.
• W2034382342 countsByYear W20343823422023 @default.
• W2034382342 crossrefType "journal-article" @default.
• W2034382342 hasAuthorship W2034382342A5016759298 @default.
• W2034382342 hasAuthorship W2034382342A5031412427 @default.
• W2034382342 hasAuthorship W2034382342A5033012154 @default.
• W2034382342 hasAuthorship W2034382342A5045004136 @default.
• W2034382342 hasAuthorship W2034382342A5053396770 @default.
• W2034382342 hasAuthorship W2034382342A5055194670 @default.
• W2034382342 hasAuthorship W2034382342A5055565095 @default.
• W2034382342 hasAuthorship W2034382342A5079845981 @default.
• W2034382342 hasAuthorship W2034382342A5080194386 @default.
• W2034382342 hasAuthorship W2034382342A5080592111 @default.
• W2034382342 hasConcept C159047783 @default.
• W2034382342 hasConcept C159654299 @default.
• W2034382342 hasConcept C203014093 @default.
• W2034382342 hasConcept C22070199 @default.
• W2034382342 hasConcept C2522874641 @default.
• W2034382342 hasConcept C2777451964 @default.
• W2034382342 hasConcept C2777546802 @default.
• W2034382342 hasConcept C2779026604 @default.
• W2034382342 hasConcept C2780689484 @default.
• W2034382342 hasConcept C2908647359 @default.
• W2034382342 hasConcept C71924100 @default.
• W2034382342 hasConcept C99454951 @default.
• W2034382342 hasConceptScore W2034382342C159047783 @default.
• W2034382342 hasConceptScore W2034382342C159654299 @default.
• W2034382342 hasConceptScore W2034382342C203014093 @default.
• W2034382342 hasConceptScore W2034382342C22070199 @default.
• W2034382342 hasConceptScore W2034382342C2522874641 @default.
• W2034382342 hasConceptScore W2034382342C2777451964 @default.
• W2034382342 hasConceptScore W2034382342C2777546802 @default.
• W2034382342 hasConceptScore W2034382342C2779026604 @default.
• W2034382342 hasConceptScore W2034382342C2780689484 @default.
• W2034382342 hasConceptScore W2034382342C2908647359 @default.
• W2034382342 hasConceptScore W2034382342C71924100 @default.
• W2034382342 hasConceptScore W2034382342C99454951 @default.
• W2034382342 hasIssue "9400" @default.
• W2034382342 hasLocation W20343823421 @default.
• W2034382342 hasLocation W20343823422 @default.
• W2034382342 hasOpenAccess W2034382342 @default.
• W2034382342 hasPrimaryLocation W20343823421 @default.
• W2034382342 hasRelatedWork W2016294562 @default.
• W2034382342 hasRelatedWork W2046107030 @default.
• W2034382342 hasRelatedWork W2051899627 @default.
• W2034382342 hasRelatedWork W2131146007 @default.
• W2034382342 hasRelatedWork W2172121343 @default.
• W2034382342 hasRelatedWork W2321018060 @default.
• W2034382342 hasRelatedWork W2350790654 @default.
• W2034382342 hasRelatedWork W2406748527 @default.
• W2034382342 hasRelatedWork W2766579578 @default.
• W2034382342 hasRelatedWork W3119534403 @default.
• W2034382342 hasVolume "362" @default.
• W2034382342 isParatext "false" @default.

• next