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- W2034383553 abstract "Iron is suspected to be involved in the induction and/or progression of various human tumors. The present study was designed to investigate the effects of iron on endothelial cells, keeping in mind that the homeostasis of microvessels plays a critical role in neo-angiogenesis. Applying a model of human dermal microvascular endothelial cell terminal differentiation and death induced by serum deprivation, we found that iron salts (iron chloride and ferric nitrilotriacetate) provided a survival advantage to endothelial cells. Using immunohistochemistry and Western Blot analysis, we found that the extended cellular life span induced by iron was paralleled by an increase of Bcl-2 protein expression. Taken together, these observations suggest that iron may give a survival advantage to endothelial cells and represent a novel mechanism through which iron may contribute to tumorigenesis." @default.
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- W2034383553 date "2001-01-01" @default.
- W2034383553 modified "2023-09-27" @default.
- W2034383553 title "Iron induces Bcl-2 expression in human dermal microvascular endothelial cells" @default.
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- W2034383553 doi "https://doi.org/10.1080/10715760100300211" @default.
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