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• W2034383590 endingPage "2030" @default.
• W2034383590 startingPage "2022" @default.
• W2034383590 abstract "Monocyte chemoattractant protein-1 (MCP-1/CCL2) has a critical role in the development of various renal diseases. Data from disease specific experimental animal models and clinical studies confirm that MCP-1 plays an important part in the pathogenesis of renal diseases. The action of MCP-1 in these studies has been shown to be more complex than the traditional concept of monocyte/macrophage recruitment to the inflammatory site. MCP-1 is expressed in renal tissues and it is detectable in urine of patients with a variety of renal diseases. Measurement of urinary levels of MCP-1 can provide valuable information not only for the diagnosis of active renal disease, but also for monitoring of response to therapy. Urinary MCP-1 measurement can provide help with evaluation of the prognosis in various renal diseases. Furthermore, selective targeting of MCP-1 could be an effective treatment in suppressing a number of renal diseases as blocking MCP-1 has already been shown to ameliorate renal diseases in experimental animal models. The advantage of measuring urinary MCP-1 rather than the conventional markers must now be validated using a larger cohort of patients in different renal diseases. Also the therapeutic potential of MCP-1 targeting agents needs to be investigated in clinical studies." @default.
• W2034383590 created "2016-06-24" @default.
• W2034383590 creator A5043815123 @default.
• W2034383590 creator A5049834556 @default.
• W2034383590 date "2011-11-01" @default.
• W2034383590 modified "2023-10-16" @default.
• W2034383590 title "Urinary monocyte chemoattractant protein-1 in renal disease" @default.
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• W2034383590 doi "https://doi.org/10.1016/j.cca.2011.07.023" @default.
• W2034383590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21851811" @default.
• W2034383590 hasPublicationYear "2011" @default.
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