FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034383851> ?p ?o ?g. }

• W2034383851 endingPage "220" @default.
• W2034383851 startingPage "213" @default.
• W2034383851 abstract "Renal superoxide excess, which is induced by an imbalance of the superoxide-producing enzyme NAD(P)H oxidase and the superoxide-scavenging enzyme superoxide dismutase (SOD) under hyperglycemia, increases oxidative stress and contributes to the development of diabetic nephropathy. In this study, we treated non-obese and hypoinsulinemic C57BL/6-Ins2Akita (C57BL/6-Akita) diabetic mice with telmisartan (5 mg kg−1 per day), an angiotensin II type 1 receptor blocker, or amlodipine (5 mg kg−1 per day), a calcium channel blocker, for 4 weeks and compared the effects of these two anti-hypertensive drugs on renal NAD(P)H oxidase, SOD and transcription factor Nrf2 (NF-E2-related factor 2), which is known to upregulate several antioxidant enzymes including SOD. Vehicle-treated C57BL/6-Akita mice exhibited higher renal NAD(P)H oxidase and lower renal SOD activity with increased levels of renal superoxide than the C57BL/6-wild-type non-diabetic mice. Interestingly, telmisartan treatment not only reduced NAD(P)H oxidase activity but also enhanced SOD activity in C57BL/6-Akita mouse kidneys, leading to a reduction of renal superoxide levels. Furthermore, telmisartan-treated C57BL/6-Akita mice increased the renal protein expression of SOD and Nrf2. In parallel with the reduction of renal superoxide levels, a reduction of urinary albumin levels and a normalization of elevated glomerular filtration rate were observed in telmisartan-treated C57BL/6-Akita mice. In contrast, treatment with amlodipine failed to modulate renal NAD(P)H oxidase, SOD and Nrf2. Finally, treatment of C57BL/6-Akita mice with apocynin, an NAD(P)H oxidase inhibitor, also increased the renal protein expression of SOD and Nrf2. Collectively, our data suggest that NAD(P)H oxidase negatively regulates renal SOD, possibly by downregulation of Nrf2, and that telmisartan could upregulate renal SOD by the suppression of NAD(P)H oxidase and subsequent upregulation of Nrf2, leading to the amelioration of renal oxidative stress and diabetic renal changes." @default.
• W2034383851 created "2016-06-24" @default.
• W2034383851 creator A5001798874 @default.
• W2034383851 creator A5009147637 @default.
• W2034383851 creator A5016507641 @default.
• W2034383851 creator A5044415438 @default.
• W2034383851 creator A5044499778 @default.
• W2034383851 creator A5055016294 @default.
• W2034383851 creator A5075630675 @default.
• W2034383851 creator A5075793122 @default.
• W2034383851 creator A5080387685 @default.
• W2034383851 creator A5086504375 @default.
• W2034383851 date "2011-11-10" @default.
• W2034383851 modified "2023-10-11" @default.
• W2034383851 title "Modulation of renal superoxide dismutase by telmisartan therapy in C57BL/6-Ins2Akita diabetic mice" @default.
• W2034383851 cites W141789558 @default.
• W2034383851 cites W1969789360 @default.
• W2034383851 cites W1976555160 @default.
• W2034383851 cites W1981905227 @default.
• W2034383851 cites W1982575337 @default.
• W2034383851 cites W1982963566 @default.
• W2034383851 cites W1985436679 @default.
• W2034383851 cites W1986836799 @default.
• W2034383851 cites W1997666142 @default.
• W2034383851 cites W2011557080 @default.
• W2034383851 cites W2012258975 @default.
• W2034383851 cites W2021869209 @default.
• W2034383851 cites W2023377229 @default.
• W2034383851 cites W2038808768 @default.
• W2034383851 cites W2040772170 @default.
• W2034383851 cites W2044773944 @default.
• W2034383851 cites W2059240823 @default.
• W2034383851 cites W2083990676 @default.
• W2034383851 cites W2097267275 @default.
• W2034383851 cites W2110182057 @default.
• W2034383851 cites W2114212244 @default.
• W2034383851 cites W2114443210 @default.
• W2034383851 cites W2115408859 @default.
• W2034383851 cites W2115724806 @default.
• W2034383851 cites W2117559470 @default.
• W2034383851 cites W2118286022 @default.
• W2034383851 cites W2121415692 @default.
• W2034383851 cites W2129697991 @default.
• W2034383851 cites W2134308098 @default.
• W2034383851 cites W2134975242 @default.
• W2034383851 cites W2135565300 @default.
• W2034383851 cites W2137973714 @default.
• W2034383851 cites W2142211652 @default.
• W2034383851 cites W2142503533 @default.
• W2034383851 cites W2145360453 @default.
• W2034383851 cites W2146242381 @default.
• W2034383851 cites W2149884828 @default.
• W2034383851 cites W2155210704 @default.
• W2034383851 cites W2155383113 @default.
• W2034383851 cites W2159691173 @default.
• W2034383851 cites W2170753465 @default.
• W2034383851 cites W2468150319 @default.
• W2034383851 cites W2471605942 @default.
• W2034383851 doi "https://doi.org/10.1038/hr.2011.176" @default.
• W2034383851 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3273720" @default.
• W2034383851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22072110" @default.
• W2034383851 hasPublicationYear "2011" @default.
• W2034383851 type Work @default.
• W2034383851 sameAs 2034383851 @default.
• W2034383851 citedByCount "40" @default.
• W2034383851 countsByYear W20343838512012 @default.
• W2034383851 countsByYear W20343838512013 @default.
• W2034383851 countsByYear W20343838512014 @default.
• W2034383851 countsByYear W20343838512015 @default.
• W2034383851 countsByYear W20343838512016 @default.
• W2034383851 countsByYear W20343838512017 @default.
• W2034383851 countsByYear W20343838512019 @default.
• W2034383851 countsByYear W20343838512020 @default.
• W2034383851 countsByYear W20343838512021 @default.
• W2034383851 countsByYear W20343838512022 @default.
• W2034383851 crossrefType "journal-article" @default.
• W2034383851 hasAuthorship W2034383851A5001798874 @default.
• W2034383851 hasAuthorship W2034383851A5009147637 @default.
• W2034383851 hasAuthorship W2034383851A5016507641 @default.
• W2034383851 hasAuthorship W2034383851A5044415438 @default.
• W2034383851 hasAuthorship W2034383851A5044499778 @default.
• W2034383851 hasAuthorship W2034383851A5055016294 @default.
• W2034383851 hasAuthorship W2034383851A5075630675 @default.
• W2034383851 hasAuthorship W2034383851A5075793122 @default.
• W2034383851 hasAuthorship W2034383851A5080387685 @default.
• W2034383851 hasAuthorship W2034383851A5086504375 @default.
• W2034383851 hasBestOaLocation W20343838511 @default.
• W2034383851 hasConcept C126322002 @default.
• W2034383851 hasConcept C134018914 @default.
• W2034383851 hasConcept C181199279 @default.
• W2034383851 hasConcept C185592680 @default.
• W2034383851 hasConcept C2775838275 @default.
• W2034383851 hasConcept C2776151105 @default.
• W2034383851 hasConcept C2779716603 @default.
• W2034383851 hasConcept C2779719074 @default.
• W2034383851 hasConcept C2779922275 @default.
• W2034383851 hasConcept C2780091579 @default.
• W2034383851 hasConcept C2780795997 @default.

• next