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- W2034384208 abstract "Adenocarcinomas of the breast behave clinically and epidemiologically in ways that show host resistance factors are important for outcome in addition to grade and stage of malignancy. Immune reactivity to autologous tumors is indicated by the general presence of lymphoid infiltration (LI) and regional lymph node changes; however, these changes predict favorable outcome only in non-metastatic disease. LI is characterized by CD4+ and CD8+ tumor infiltrating lymphocytes reflecting latent cell-mediated immunity (CMI). CMI and humoral immune reactivity have been demonstrated to autologous tumor and a variety of tumor-associated antigens (TAA) have been implicated including CEA, HER-2/neu, MAGE-1, p53, T/Tn and MUC-1. Immune incompetence involving CMI is progressive with the stage of breast cancer and is prognostically significant. Immunotherapy of several types has been designed to address this immunodeficiency and the TAAs involved. Animal models have employed drug therapy, cytokine transfection, vaccines with autologous tumor, cytokines like interferon alpha (IFN-alpha) and interleukin-2 (IL-2), TAA tumor vaccines, and immunotoxins with evidence of tumor regression by immunologic means. Immunotherapy of human breast cancer is a rapidly growing experimental area. Positive results have been obtained with natural IFN and interleukins, particularly in combination strategies (but not with high dose recombinant IFN or IL-2), with autologous tumor vaccine (but not yet with transfected autologous tumor); with a mucin carbohydrate vaccine (Theratope) in a combination strategy (but not with mucin core antigen) and with several immunotoxins. Combination strategies involving immunorestoration, contrasuppression, adjuvant, and immunotoxins are suggested for the future." @default.
- W2034384208 created "2016-06-24" @default.
- W2034384208 creator A5010133192 @default.
- W2034384208 date "1999-03-01" @default.
- W2034384208 modified "2023-10-06" @default.
- W2034384208 title "Review Article The immunology and immunotherapy of breast cancer: an update" @default.
- W2034384208 cites W116613973 @default.
- W2034384208 cites W126392675 @default.
- W2034384208 cites W131924137 @default.
- W2034384208 cites W1445322489 @default.
- W2034384208 cites W150077939 @default.
- W2034384208 cites W1513644368 @default.
- W2034384208 cites W1522722282 @default.
- W2034384208 cites W1599327500 @default.
- W2034384208 cites W1630308865 @default.
- W2034384208 cites W1655423342 @default.
- W2034384208 cites W166077715 @default.
- W2034384208 cites W1853173850 @default.
- W2034384208 cites W189180021 @default.
- W2034384208 cites W193028052 @default.
- W2034384208 cites W1931089671 @default.
- W2034384208 cites W1951776719 @default.
- W2034384208 cites W1964481268 @default.
- W2034384208 cites W1965857260 @default.
- W2034384208 cites W1967019771 @default.
- W2034384208 cites W1971992475 @default.
- W2034384208 cites W1973855239 @default.
- W2034384208 cites W1975878941 @default.
- W2034384208 cites W1976485037 @default.
- W2034384208 cites W1976719626 @default.
- W2034384208 cites W1978625008 @default.
- W2034384208 cites W1979680380 @default.
- W2034384208 cites W1981919340 @default.
- W2034384208 cites W1983258178 @default.
- W2034384208 cites W1985215200 @default.
- W2034384208 cites W1987461992 @default.
- W2034384208 cites W1990389197 @default.
- W2034384208 cites W1990574224 @default.
- W2034384208 cites W1991952914 @default.
- W2034384208 cites W1993912785 @default.
- W2034384208 cites W1994793713 @default.
- W2034384208 cites W1995006264 @default.
- W2034384208 cites W1995611890 @default.
- W2034384208 cites W2000551412 @default.
- W2034384208 cites W2001798961 @default.
- W2034384208 cites W2002979890 @default.
- W2034384208 cites W2005170379 @default.
- W2034384208 cites W2005477050 @default.
- W2034384208 cites W2008535199 @default.
- W2034384208 cites W2008581311 @default.
- W2034384208 cites W2009870709 @default.
- W2034384208 cites W2009967743 @default.
- W2034384208 cites W2010848533 @default.
- W2034384208 cites W2011630727 @default.
- W2034384208 cites W2011792959 @default.
- W2034384208 cites W2012590163 @default.
- W2034384208 cites W2014487380 @default.
- W2034384208 cites W2015077630 @default.
- W2034384208 cites W2015962444 @default.
- W2034384208 cites W2017627040 @default.
- W2034384208 cites W2020661373 @default.
- W2034384208 cites W2022025364 @default.
- W2034384208 cites W2022248729 @default.
- W2034384208 cites W2025342394 @default.
- W2034384208 cites W2027398799 @default.
- W2034384208 cites W2029844324 @default.
- W2034384208 cites W2030568053 @default.
- W2034384208 cites W2033978532 @default.
- W2034384208 cites W2036013383 @default.
- W2034384208 cites W2040949270 @default.
- W2034384208 cites W2043092551 @default.
- W2034384208 cites W2043707365 @default.
- W2034384208 cites W2043855966 @default.
- W2034384208 cites W2044116106 @default.
- W2034384208 cites W2045143812 @default.
- W2034384208 cites W2046451852 @default.
- W2034384208 cites W2048116810 @default.
- W2034384208 cites W2056874260 @default.
- W2034384208 cites W2058065532 @default.
- W2034384208 cites W2059631520 @default.
- W2034384208 cites W2060593922 @default.
- W2034384208 cites W2060783173 @default.
- W2034384208 cites W2063302960 @default.
- W2034384208 cites W2064022465 @default.
- W2034384208 cites W2064517738 @default.
- W2034384208 cites W206480088 @default.
- W2034384208 cites W2064932721 @default.
- W2034384208 cites W2068467321 @default.
- W2034384208 cites W2069545588 @default.
- W2034384208 cites W2069898717 @default.
- W2034384208 cites W2070154027 @default.
- W2034384208 cites W2070522239 @default.
- W2034384208 cites W2075847417 @default.
- W2034384208 cites W2076870798 @default.
- W2034384208 cites W2077503166 @default.
- W2034384208 cites W2078423573 @default.
- W2034384208 cites W2078742602 @default.
- W2034384208 cites W2080196003 @default.