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• W2034384613 abstract "Prostaglandin H synthase catalyzes the first step in the synthesis of prostaglandins from arachidonic acid. The peroxidase activity of this enzyme can support the oxidation of xenobiotics, particularly aromatic amines. This pathway of metabolism may contribute to the activation of carcinogenic aromatic amines in target tissues such as the skin, lung, and bladder. In this review, recent work on this subject is summarized. I emphasize the elucidation of the structures of aromatic amine oxidation products, and their interactions with biological macromolecules. Prostaglandin H synthase supports the activation of benzidine to a mutagenic species in the Ames (Salmonella typhimurium) test, and our studies of the mechanism of this activation are described." @default.
• W2034384613 created "2016-06-24" @default.
• W2034384613 creator A5026129168 @default.
• W2034384613 date "1989-01-01" @default.
• W2034384613 modified "2023-10-12" @default.
• W2034384613 title "Activation of aromatic amines by prostaglandin H synthase" @default.
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• W2034384613 doi "https://doi.org/10.1016/0891-5849(89)90046-4" @default.
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